Model: Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.
Dosage: Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of Kluyveromyces fragilis yeast extract, 350 mg of Saccharomyces cerevisiae yeast extract, or a placebo.

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Brain &amp; Neurons

Model: 5xFAD mouse model for Alzheimer’s disease 
Dosage: Oral administration of 457 mg/kg/day of glucosamine for 2 weeks

Supplementing with glucosamine, a compound found in our cartilage, increases the risk of mortality from dementia in certain individuals while also worsening memory in mice that model dementia. 

Study led by Dr. Ramon Sun on the far right (image: mbi.ufl.edu). 

Model: Six adults who received intravenous NAD+ and eight adults who received intravenous NR
Dosage: 500 mg of intravenous NAD+ or 500 mg of intravenous NR daily for four consecutive days

Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions

A Stanford study supports the short-term safety of NAD+ and NR infusion therapies, and participants who received NR infusions exhibited significantly lower HbA1c (a blood test that reflects average blood sugar over two to three months).

(An IV bag containing a solution with NAD+ | Crete Fertility Centre)

A Stanford human trial provides the first data supporting the safety of NAD+ IV and NR IV therapies.

Model: Old male mice
Dosage: 100 mg/kg/day of ALA administered in drinking water

Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

Aging &amp; Longevity

Russia’s $27 Billion Bet on Beating Aging—Hype or Hope?

With an ambitious goal of conquering aging, Russia is investing $26 to $28 billion in a national health initiative.

(Russian leader, Vladimir Putin | RBC-Ukraine)

Search Result: RNA

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Common Joint Health Supplement May Progress Dementia, New Study Finds

Pilot Human Study Supports Safety of NAD+ IV and NR IV Infusions

Alpha-Lipoic Acid Rejuvenates Stem Cells & Improves Gut, New Study Shows

Russia’s $27 Billion Bet on Beating Aging—Hype or Hope?