Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

Does NAD+ (nicotinamide adenine dinucleotide) really help with aging? A team of international scientists reviews the latest and ongoing clinical trials.

Part of the research team, including Dr. Evandro Fei Fang (middle), from the University of Oslo and Akershus University Hospital in Norway (image: med.uio.no). 

Removing an NAD+ transporter called SLC25A51 from insulin-secreting cells mitigates diabetes and reduces senescent cells — cells that contribute to the pathology of age-related diseases.  


Principal investigator Nora Kory, PhD, from Harvard University (image: harvard.edu). 

Four FDA-Approved Drugs that Reduce Chances of Aging-Related Death

Dr. Nir Barzilai, the director of aging research at Albert Einstein College of Medicine, discusses the science behind SGLT2 inhibitors, metformin, bisphosphonates, and GLP-1 agonists.

Dr. Nir Barzilai, the director of aging research at Albert Einstein College of Medicine, relays that we have four FDA-approved drugs that lower human mortality: SGLT2 inhibitors, bisphosphonates, metformin, and GLP-1 agonists.

Paul Saladino, M.D., refutes the mainstream view that red meat shortens lifespan and explains how eating red meat could potentially reverse aging. 


Dr. Paul Saladino (Image: davesprey.com).

Dr. Paul Saladino says that red meat reverses aging, contrary to the mainstream idea of red meat accelerating aging. 

Search Result: Prediabetes

Top Evidence-Based Interventions to Lower Biological Age

NAD+ and Aging: What the Latest Research Says

NAD+ & Diabetes: Harvard Study Reveals New Anti-Aging Key

Four FDA-Approved Drugs that Reduce Chances of Aging-Related Death

Paleo Doctor Challenges Mainstream Scientists: Red Meat Reverses Aging