<p>Model: Young acquired niacin dependency (ANDY) mice. </p>
<p>Dosage: 30 mg/kg/day of niacin </p>


Mice engineered to have low body-wide NAD+ levels exhibit a shortened lifespan and widespread physical decline, which is largely reversed with the NAD+ booster niacin. 

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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

<p>Model: 27-month-old male C57BL/6N mice </p>
<p>Dosage: 50 mg/kg/day of fisetin for 1 week, followed by no treatment for 2 weeks, followed by another week of treatment  </p>


Plant-based molecule fisetin preserves muscle mass and strength in older mice via senolytic action — removal of senescent (dysfunctional) cells.


Study conducted at the University of Colorado Boulder (image: govtech.com) 

Skin &amp; Muscle

Columbia University scientists find that senolytics — compounds that remove age-promoting cells — restore hair follicle regeneration in a human cell/mouse model. 

<p>Model: 16-month-old female C57BL/6 mice </p>
<p>Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again </p>


A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Search Result: Navitoclax

New Mayo Clinic Study: Forcibly Depleting NAD+ Shortens Lifespan

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Fisetin Fights Frailty: New Study Shows Supplment Preserves Strength

Can Senolytic Supplements Restore Hair Growth? What the New Research Says

Which Anti-Aging Senolytic Supplement Should You Avoid?