Model: 3-month-old LDLR−/− pigs
Dosage: 400 nM of SWNT or SWNT-SHP1i 
was infused intravenously for ~15–30 min, once a week, for 12 weeks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis 

Stanford School of Medicine researchers develop safe nanoparticles that target dying cells in atherosclerotic plaque and reduce vascular inflammation.

Cardiovascular

Model: APP/PS1 Alzheimer&#8217;s Disease mice
Dosage: 10 mg/kg/day Au NPs

A new study showed that when mice with Alzheimer’s disease ate gold particles, they had less brain inflammation and cognitive decline.

Brain &amp; Neurons

Model: Wistar rats 
Dosage: 4 g/kg grapeseed flour

Feeding rats large amounts of grapeseed flour significantly increases their lifespan and elevates their NAD+/NADH ratio — an indicator of optimized NAD+ metabolism — in multiple organs. 


Grapes and grapeseed flour | Image: Originally Africa (not a sponsor of this study)

Aging &amp; Longevity

Model: Male C57BL/6 mice exposed to lipopolysaccharide (LPS) to induce septic shock
Dosage: 40 mg NAD+ (probably injected, but not clear from the publication)

NAD+ reduces inflammation and increases the survival of mice subjected to an overactive immune response known as sepsis. 


Lead investigator Dr. Jasper Iske | LinkedIn

Discover groundbreaking insights from Harvard scientists as they unveil the incredible role of NAD+ in modulating the immune system. Explore how this powerful mechanism acts as a shield, protecting the body against inflammatory threats. Dive into the science at NAD.com/news.

Unlocking Immune Power: Harvard Scientists Reveal How NAD+ Modulates the Immune System to Guard Against Inflammatory Assault

Immunity

Manipulating Aging Through Cutting-Edge Gene Therapies

Gene therapy techniques like CRISPR and RNA replacement compensate for or replace defective longevity-associated genes like KLOTHO or FOXO genes.

(A scientist in a laboratory performing gene therapy research)

Researchers continue to develop ways to substitute, edit, and delete gene sequences to engineer and improve the expression of certain genes related to aging.

Search Result: Nanoparticles

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis

Researchers Use Gold Nanoparticles to Treat Neurodegenerative Disease

Study Reveals Surprising Benefits of Grapeseed Flour: Increased Lifespan and Multi-Organ NAD+ Rejuvenation

Harvard Scientists Find NAD⁺ Protects Against Life-Threatening Inflammation

Manipulating Aging through Cutting-Edge Gene Therapies