Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Johns Hopkins Research Review: Parkinson’s Drug Extends Multiple Species' Lifespan

L-deprenyl, a drug used to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend lifespan across species, from mice to rats to hamsters.

L-deprenyl, a drug prescribed to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend average lifespan across mammalian model organism species.

Aging &amp; Longevity

Dose: 20 mg/kg, five days a week
Administration: intraperitoneal (abdominal cavity)injection

Turmeric Metabolite Improves Age-Related Memory Deficits

Mexican scientists show that curcumin — the primary metabolite found in turmeric — improves learning and memory while increasing neuroplasticity and reducing inflammation in the brain of aged mice. 


A new study shows that fisetin, a senolytic compound, reduces depression-like behavior in mice with brain inflammation.

A senolytic medication that destroys growth-arrested brain cells is being used by Japanese researchers to treat depression in lupus patients.

By looking at secreted sacs from brain cells in blood, UCSF School of Medicine researchers find abnormal levels of mitochondrial and NAD+ metabolism proteins tied to major depressive disorder.

Scientists from the University of California, San Francisco find abnormal levels of mitochondrial and NAD+-metabolism proteins linked to major depressive disorder.

Search Result: Major Depressive Disorder

High Protein Intake Promotes Aging by Lowering NAD+ Levels

Johns Hopkins Research Review: Parkinson’s Drug Shown to Extend Lifespan Across Mammalian Species

Study Shows that Curcumin Improves Learning and Memory in Older Mice

Japanese Researchers Show Fisetin Alleviates Depression

Study Links Depression to Reduced Levels of NAD⁺-Producing Protein