Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Johns Hopkins Research Review: Parkinson’s Drug Extends Multiple Species' Lifespan

L-deprenyl, a drug used to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend lifespan across species, from mice to rats to hamsters.

L-deprenyl, a drug prescribed to treat Parkinson’s disease and major depressive disorder, has been shown to modestly extend average lifespan across mammalian model organism species.

Dose: 20 mg/kg, five days a week
Administration: intraperitoneal (abdominal cavity)injection

Turmeric Metabolite Improves Age-Related Memory Deficits

Mexican scientists show that curcumin — the primary metabolite found in turmeric — improves learning and memory while increasing neuroplasticity and reducing inflammation in the brain of aged mice. 


A new study shows that fisetin, a senolytic compound, reduces depression-like behavior in mice with brain inflammation.

A senolytic medication that destroys growth-arrested brain cells is being used by Japanese researchers to treat depression in lupus patients.

Search Result: Major Depressive Disorder

Top Evidence-Based Interventions to Lower Biological Age

High Protein Intake Promotes Aging by Lowering NAD+ Levels

Johns Hopkins Research Review: Parkinson’s Drug Shown to Extend Lifespan Across Mammalian Species

Study Shows that Curcumin Improves Learning and Memory in Older Mice

Japanese Researchers Show Fisetin Alleviates Depression