Model: 20-month-old C57BL/6N male mice (roughly equivalent to 60-year-old humans)
Dosage: 8,000 mg/kg of taurine administered daily via oral gavage for four months

Yale Study Shows How Taurine Reduces Age-Related Inflammation

A new study reveals how taurine helps curb age-related inflammation in aged mice by targeting a key inflammatory pathway in immune cells.

A new study finds that taurine supplementation reduces signs of inflammation and improves some measures of physical function in aged male mice.

Aging &amp; Longevity

Model: Young C57BL/6J mice fed a high protein (56% of daily calories) diet for 20 weeks 
Dosage: Injection with either 400 mg/kg of NMN or 20 mg/kg of 78c for 4 weeks

High protein intake improves the body composition of aged mice, but it lowers NAD+ (nicotinamide adenine dinucleotide) levels and promotes metabolic aging. 

Metabolism

Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Cardiovascular

Model: 3-month-old LDLR−/− pigs
Dosage: 400 nM of SWNT or SWNT-SHP1i 
was infused intravenously for ~15–30 min, once a week, for 12 weeks

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis 

Stanford School of Medicine researchers develop safe nanoparticles that target dying cells in atherosclerotic plaque and reduce vascular inflammation.

Search Result: Macrophages

Yale Study Shows How Taurine Reduces Age-Related Inflammation

High Protein Intake Promotes Aging by Lowering NAD+ Levels

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

“Trojan Horse” Nanoparticles: A Breakthrough in Treatment for Atherosclerosis