Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

Model: Humans between the ages of 21 and 72
Dosage: Oral dosage of 500 mg of nicotinamide, 600 mg of alpha lipoic acid, 10 mg of zinc, 20 mg of vitamin C, and 2,110 mg of a botanical blend containing green tea extract, rutin, parsley leaf extract, and black pepper fruit daily for 28 days

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

British researchers designed a nutraceutical to maximize nicotinamide adenine dinucleotide (NAD+) levels that significantly lowers biological age.

British researchers used a nutraceutical targeting multiple NAD+ biosynthesis- and breakdown-related enzymes to increase NAD+, lower inflammation, and increase sirtuins.

Based primarily on discussions with guests on his popular podcast, the supplements Joe Rogan has taken include NMN, resveratrol, vitamin D, fish oil, and more.  



Joe Rogan (Image: Joe Rogan’s X account) 

The supplements that Joe Rogan has taken, according various social media posts and conversations he's had with guest on his podcast. 

Doctor Claims Salt in Processed Foods Is Killing Us

According to Dr. Michael Greger, about 25% of lifespan is determined by genetics — making the vast majority of early deaths preventable — and avoiding sodium in processed foods is a major way to do so.

Dr. Michael Greger recommends reducing sodium from preservatives, eating dark green vegetables, and keeping company with health-conscious people to prevent an early death.

Aging &amp; Longevity

Model: Male Swiss albino mice
Dosage: 100 mg/kg per day for 18 months

New Study: Green Tea Molecule Extends Lifespan and Alleviates Fat Tissue Senescence

Epigallocatechin gallate (EGCG) supplementation substantially prolongs lifespan and suppresses senescence — an age-related, dysfunctional cellular state — in the fat tissue of mice.

(An aged mouse drinking green tea with an EGCG molecule on the left | NAD.com)

EGCG supplementation over 18 months increases median lifespan by ~25% and significantly lowers fat tissue senescence in mice.

Search Result: EGCG

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

A New, Multifaceted Approach to Increasing Cellular NAD+ Levels

Podcaster Joe Rogan’s Top 2024 Supplements Beyond NAD+ Precursor NMN

Doctor Claims Salt in Processed Foods Is Killing Us

New Study Reveals Green Tea Molecule Extends Lifespan and Alleviates Fat Tissue Senescence