Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Brain &amp; Neurons

The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


The longevity gene klotho prolongs the lifespan of mice while preventing muscle, bone, and brain aging. 

Miguel Chillón, PhD, and Laura Rodriguez-Estevez, researchers from Universitat Autònoma de Barcelona in Spain, who conducted the study (image: uab.cat) 

Aging &amp; Longevity

<p>Participants: Middle-aged adults carrying two copies of the APOE4 gene </p>
<p>Dosage: 1 mg/kg/day of rapamycin for 4 weeks </p>


The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

By reducing brain inflammation, apigenin may protect against cognitive decline associated with aging, according to research out of Colorado State University.


Explore apigenin's benefits for brain health: reducing inflammation, enhancing memory, and protecting against aging-related cognitive decline.

Search Result: Astrocytes

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

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Research Supports Apigenin’s Anti-Aging Benefits on The Brain