Model: 22-month-old male C57BL/6NIH mice 
Dosage: 400 mg/kg of NR for eight weeks, administered in food

Treating aged mice with the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) improves memory and reduces pro-inflammatory immune cells.

Senior members of the research team, Dr. Bruce R. Troen and Dr. Kenneth L. Seldeen (image: buffalo.edu).  

Brain &amp; Neurons

Model: Ten-month-old male EFAD mice 
Dosage: 14.4 ppm of alfatradiol in diet for five months

USC Study: Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer's

The drug alfatradiol, also known as 17ɑ-estradiol, reduces cognitive errors on a test of memory and lowers neuronal plaques in mice genetically predisposed to Alzheimer’s disease.

(The University of Southern California | College Matchpoint)

Researchers unveil data suggesting the drug alfatradiol improves signs of frailty, reduces cognitive errors, and reduces neuronal plaques in mice with a genetic predisposition to Alzheimer’s disease.

Cognitive deficits were reduced by 52% in Alzheimer’s disease patients receiving transcranial magnetic stimulation (TMS) — a technique that stimulates the brain’s electrical activity. 


Lead researcher Giocomo Koch, MD, PhD, uses a TMS device on an individual wearing an electroencephalogram (EEG) cap (image: domussantarita.it). 

The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


Studies suggest that supplementation with melatonin may slow brain aging, thereby improving cognition. 

Search Result: Alzheimers Dementia

NAD+ Supplement Improves Memory & Brain Immune Cells, New Study Reveals

USC Study Suggests Longevity-Promoting Drug Counteracts a Genetic Predisposition to Alzheimer’s

Accessing Technology that Reduces Alzheimer’s Memory Loss by 52%

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging

Does Melatonin Improve Cognition? What the Latest Research Says