Model: 27-month-old male C57BL/6N mice 
Dosage: 50 mg/kg/day of fisetin for 1 week, followed by no treatment for 2 weeks, followed by another week of treatment

Plant-based molecule fisetin preserves muscle mass and strength in older mice via senolytic action — removal of senescent (dysfunctional) cells.


Study conducted at the University of Colorado Boulder (image: govtech.com) 

Skin &amp; Muscle

Model: C57BL/6N mice 
Dosage: 1 g/kg carvedilol in food for one week followed by four weeks of PAGln treatment, consisting of 50 mg/kg per day by injection, and the same PAGln treatment for four weeks followed by 50 mg/kg per day of ABT263 via oral gavage for five days

New Study Suggests Combining Senolytics with Blood Pressure Medication Counteracts an Aging Gut

Carvedilol, a blood pressure medication, and the senolytic agent ABT-263 both attenuate cellular senescence—an age-related, dysfunctional cellular state—driven by a gut bacterial metabolite in mice.

Aging &amp; Longevity

Columbia University scientists find that senolytics — compounds that remove age-promoting cells — restore hair follicle regeneration in a human cell/mouse model. 

Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Model: 27-month-old male C57BL/6N mice 
Intermittent Dosing (oral): 1 week of 100 mg/kg/day of fisetin, followed by 2 weeks of no intervention, followed by 1 week of 100 mg/kg/day of fisetin

Fisetin supplementation counteracts artery aging in old mice by preserving artery elasticity and function via senolytic action — removal of senescent (dysfunctional) cells.  


Lead investigator Sophia Mahoney | University of Colorado Boulder

Search Result: ABT-263

Fisetin Fights Frailty: New Study Shows Supplment Preserves Strength

Combining Senolytics with Blood Pressure Medication Counteracts Gut Aging and Promotes Longevity, Suggests New Study

Can Senolytic Supplements Restore Hair Growth? What the New Research Says

Which Anti-Aging Senolytic Supplement Should You Avoid?

Senolytic Compound Fisetin Preserves Artery Wall Elasticity to Combat Cardiovascular Disease