Columbia University scientists find that senolytics — compounds that remove age-promoting cells — restore hair follicle regeneration in a human cell/mouse model. 

Skin &amp; Muscle

Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Others

Model: 27-month-old male C57BL/6N mice 
Intermittent Dosing (oral): 1 week of 100 mg/kg/day of fisetin, followed by 2 weeks of no intervention, followed by 1 week of 100 mg/kg/day of fisetin

Fisetin supplementation counteracts artery aging in old mice by preserving artery elasticity and function via senolytic action — removal of senescent (dysfunctional) cells.  


Lead investigator Sophia Mahoney | University of Colorado Boulder

Cardiovascular

Scientists maintain the function of fat-derived stem cells by boosting NAD+ with nicotinamide riboside (NR), which could combat age-related liver and muscle ailments.



A woman next to a nicotinamide riboside (NR) molecule. 

Model: Male Titan mice
Dose (oral): 50 mg/kg of Navitoclax for 5 days followed by 16 day break repeated 5 times

German scientists cut the weight of obese mice and prolong their lifespan by 16.7% by reducing senescent age-driving cells with the senolytic Navitoclax.  



Most of the study’s investigators (from left to right): Annika Muller-Eigner, Dr. Shahaf Peleg, Shari Gottschalk, Benedikt Gille, and Verena Hofer-Pretz | Shahaf Peleg Lab 

Explore the findings of a groundbreaking German study showcasing how Senolytic therapy leads to weight loss and increased lifespan in obese mice. Learn about the promising implications for obesity management and longevity in this exclusive report from NAD.com.

Search Result: ABT-263

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Senolytic Compound Fisetin Preserves Artery Wall Elasticity to Combat Cardiovascular Disease

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German Study Demonstrates Senolytic Therapy Helps Obese Mice Lose Weight and Live Longer