Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

blood-cancer

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Lobster Leviathan God: Can Lobsters Live Forever?

An expired campaign to help a lobster continually molt raises the question of whether lobsters are immortal. 

lobster_god

Stanford’s Dr. Andrew Huberman Reveals His Supplement Protocol for Optimizing Health and Performance 

Stanford scientist Dr. Andrew Huberman shares his blueprint for developing a supplementation routine to optimize health and performance. 



andrew-huberman

andrew huberman

Dr. Andrew Huberman (Photograph courtesy of Mike Blabac; Collage: Gabe Conte)

Explore Dr. Huberman's methods for health and optimization through strategic supplementation and behavioral protocols. 

Aging &amp; Longevity

Models:
<ul>
<li style="font-weight: 400;" aria-level="1">Cultured human lung fibroblasts with five types of senescence: Etoposide,  P16INK4a over-expression, KRAS, replicative, and UV</li>
<li style="font-weight: 400;" aria-level="1">Irradiated or naturally aged (24 months old) mice were treated with mock- or mNKG2D-CAR T; irradiation-accelerated mouse model of aging, wild-type C57BL/6 mice (8 to 10 weeks old)</li>
<li style="font-weight: 400;" aria-level="1">Three rhesus macaques and two cynomolgus macaques</li>
</ul>
Dosage: NKG2D-CAR T cells

Scientists Engineer Immune Cells that Can Hunt Down and Eliminate Aging Cells

A study demonstrates that engineered immune cells can serve as potent and selective medicine for cells at the center of aging and age-associated diseases. 


immune_cell_soldier

Immunity

Nutrition For Longevity: Optimizing Lifespan Through Dietary Choices

Nourishing the body with healthy dietary choices, including caloric restriction, time-restricted feeding, and plant-based diets enhances overall well-being and promotes longevity. 

strength-training2

strength training2

Model: C57BL/6 Ercc1 +/- mice
Dosage: 11% oxygen chamber

Breaking News: Harvard Study Shows Lower Oxygen Levels Drive Longer Lifespan 

Researchers show that oxygen restriction (hypoxia) increases median lifespan by approximately 50% and improves motor coordination in mice modeling accelerated aging. 


hypoxia-mid2

hypoxia mid2

Rendering of old man in oxygen-restricted chamber 

Model: 18-month-old CD45.2 mice
Dosage: 4 ug Netrin-1 via injection; 5 injections total; once every 35 days

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Infusing blood with a molecule critical for development, Netrin-1, improves the bone marrow niche in older people and restores the function of older blood stem cells, which has the potential to help people live longer.


Basic Research

Harvard and MIT Discover New Anti-Aging Drugs Using AI

By training AI to screen over 800,000 molecules, MIT and Harvard University researchers identified thousands of candidate compounds that can improve aging.


felix-wong-mit

felix wong mit

Does Pursuing a Superhero Physique through Steroid Use Accelerate Aging? 

Research in the past few decades suggests a strong association between impaired cardiac health and long-term use of anabolic steroids. 


handsomemanwithbigmusclesposingatthecamerain

Handsome,Man,With,Big,Muscles,,Posing,At,The,Camera,In

Longevity Interventions for Age-related DNA Changes

Epigenetics – changes to DNA expression rather than alteration of the DNA itself – may be the new frontier for anti-aging interventions, with researchers and doctors uncovering the ways in which epigenetics regulate age-related diseases and developing therapies to target these epigenetic changes.


dnadoublehelixillustration-humandnaspiralformedfromnucleotide

Dna,Double,Helix,Illustration.,Human,Dna,Spiral,Formed,From,Nucleotide

Sirtuins, Lifespan Extension, and Aging

Sirtuins are a family of seven enzymes found in every cell that participate in several critical biological processes known to counter aging, like cellular energy optimization and DNA repair.

Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments