Scientists repurposed a blood cancer treatment using genetically modified immune cells called CAR T cells to reverse age-associated tissue damage.

blood-cancer

A cellular therapy typically used against blood cancer called CAR T therapy improved tissue health by destroying senescent cells in mice.

Nutrition Nurtures Longevity: Optimizing Lifespan Through Dietary Choices

Nourishing the body with healthy dietary choices, including caloric restriction, time-restricted feeding, and plant-based diets enhances overall well-being and promotes longevity. 

strength-training2

strength training2

Aging &amp; Longevity

Model: C57BL/6 Ercc1 +/- mice
Dosage: 11% oxygen chamber

Breaking News: Harvard Study Shows Lower Oxygen Levels Drive Longer Lifespan 

Researchers show that oxygen restriction (hypoxia) increases median lifespan by approximately 50% and improves motor coordination in mice modeling accelerated aging. 


hypoxia-mid2

hypoxia mid2

Rendering of old man in oxygen-restricted chamber 

Model: 18-month-old CD45.2 mice
Dosage: 4 ug Netrin-1 via injection; 5 injections total; once every 35 days

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Infusing blood with a molecule critical for development, Netrin-1, improves the bone marrow niche in older people and restores the function of older blood stem cells, which has the potential to help people live longer.


Basic Research

Harvard and MIT Discover New Anti-Aging Drugs Using AI

By training AI to screen over 800,000 molecules, MIT and Harvard University researchers identified thousands of candidate compounds that can improve aging.


felix-wong-mit

felix wong mit

Does Pursuing a Superhero Physique through Steroid Use Accelerate Aging? 

Research in the past few decades suggests a strong association between impaired cardiac health and long-term use of anabolic steroids. 


handsomemanwithbigmusclesposingatthecamerain

Handsome,Man,With,Big,Muscles,,Posing,At,The,Camera,In

Longevity Interventions for Age-related DNA Changes

Epigenetics – changes to DNA expression rather than alteration of the DNA itself – may be the new frontier for anti-aging interventions, with researchers and doctors uncovering the ways in which epigenetics regulate age-related diseases and developing therapies to target these epigenetic changes.


dnadoublehelixillustration-humandnaspiralformedfromnucleotide

Dna,Double,Helix,Illustration.,Human,Dna,Spiral,Formed,From,Nucleotide

Sirtuins, Lifespan Extension, and Aging

Sirtuins are a family of seven enzymes found in every cell that participate in several critical biological processes known to counter aging, like cellular energy optimization and DNA repair.

sirtuin

Model: Female C57BL/6J mice 
Dosage: 10 mg/kg by oral gavage twice weekly

Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline

With a plant-based polyphenol called THSG, scientists delay ovarian aging and egg cell decline by boosting sex hormone activity in mice. 


thsg-pic4

THSG pic4

Jacqueline Whang-Peng, Corresponding Author 

4-week-old, 8-week-old, and 36-month-old Sprague Dawley rats
Lycopene: 100 mg/kg IP injection

Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Wuhan University researchers show that  lycopene - an antioxidant found in plants - prevents insulin resistance and promotes blood vessel growth in aged rats. 


foodsrichinlycopenewithstructuralchemicalformulaoflycopene

Foods,Rich,In,Lycopene,With,Structural,Chemical,Formula,Of,Lycopene

Metabolism

Model: C57BL/6J mice
Dosage: 5 mg/kg dasatinib (D) + 50 mg/kg quercetin (Q)

Scientists find that old mice treated with the senolytics dasatinib plus quercetin (D+Q) heal from bone fractures like young mice.


main-image-under-400-kb

main image under 400 kB

Dr. Lianping Xing & Her Team | University of Rochester Medical Center

Blood Cancer Therapy May Provide a Strategy for Age-Related Disease Treatments

Nutrition Nurtures Longevity: Optimizing Lifespan Through Dietary Choices

Breaking News: Harvard Study Shows Lower Oxygen Levels Drive Longer Lifespan

Researchers Rejuvenate Aged Mouse Blood Stem Cells

Harvard and MIT Discover New Anti-Aging Drugs Using AI

Does Pursuing a Superhero Physique through Steroid Use Accelerate Aging?

Longevity Interventions for Age-Related DNA Changes

Sirtuins, NAD⁺, Lifespan Extension, and Aging

New Study Shows Resveratrol Derivative Delays Ovarian Aging and Egg Cell Decline

Study Suggests Tomato Compound Prevents Signs of Diabetes and Reverses Blood Vessel Aging

Senolytics Restore Bone Healing Capacity in Older Age