Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Aging &amp; Longevity

A molecule known as miR-302b prolongs the life of mice by “waking up” senescent cells — “sleeping” cells that contribute to life-shortening chronic diseases. 

Depiction of microRNA molecules (Image: Artur Plawgo/iStock Photo/MIT.edu). 

Scientists cure type 2 diabetes by replicating the function of the pancreas with stem cells. 


Diabetes &amp; Obesity

Model: Human skin from 78 to 91-year-old men transplanted into mice
Dosage: 50 mg/kg/day intraperitoneal injections of Navitoclax (ABT-263)

Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study

A new study shows that the senolytic Navitoclax can counter the buildup of inflammation-inducing senescent (aged) cells to improve skin structural resilience in mice with human skin grafts.

Navitoclax reduces the abundance of skin senescent cells with age, diminishes the inflammatory molecules from senescent cells, and improves the skin’s structural resilience.

Search Result: wrinkles

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

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Senolytic Agent Rejuvenates Aged Human Skin: Japanese Study