Model: Female Balb/c mice exposed to ultraviolet radiation 
Dosage: 2%, 5%, 7.5%, or 12.5% of nicotinamide (weight/volume) applied topically, once daily, five times per week

The NAD+ (nicotinamide adenine dinucleotide) precursor nicotinamide prevents skin aging, in part by targeting age-promoting senescent cells in mice. 


Ranked fourth on the Rejuvenation Olympics leaderboard, 30-year-old Siim Land lists the supplements he takes to stay young. 


Aging &amp; Longevity

Based on human evidence, Harvard and MIT scientists determine the most promising anti-aging interventions, including NAD+ precursors, spermidine, and senolytics. 


MIT’s Leonard Guarente, Ph.D. (image: amacad.org), Harvard’s David Sinclair, Ph.D. (image: buckinstitute.org), and University of Paris Descartes’ Guido Kromer, Ph.D., M.D. (image: createcures.org). 

David Sinclair and fellow top aging biology researchers review clinical trials pertaining to the eight anti-aging compounds. 

Topically applying human hair follicles with the longevity-associated compound rapamycin increases hair coloration capacity and prolongs hair growth duration time. 


Principal investigator Dr. Ralf Paus (middle) | wfm-muenster.de

Search Result: topical

NAD+ Booster Nicotinamide Counters Skin Aging and Cell Senescence, New Study Shows

Fourth Slowest Ager in World Siim Land’s 2025 Longevity Supplement Protocol

David Sinclair and Colleagues Summarize 8 Anti-Aging Medicines Applicable to Humans

New Study Suggests Rapamycin Can Reverse Hair Graying and Promote Hair Growth