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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


Aging &amp; Longevity

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Human trials report that GlyNAC and exercise regimens improve dysfunction of the cell’s powerhouses (mitochondria), inflammation, muscle strength, and cognition.

(Some GlyNAC tablets above the chemical structure of GlyNAC | Vitamin Retailer)

GlyNAC supplementation and exercise alleviate mitochondrial dysfunction, lower inflammation, increase muscle strength, and bolster cognition.

Skin &amp; Muscle

<p><span style="font-weight: 400;">Model: Old male mice</span></p>
<p><span style="font-weight: 400;">Dosage: 100 mg/kg/day of ALA administered in drinking water </span></p>


Restoring the naturally occurring antioxidant, alpha-lipoic acid (ALA), to the gut wall rejuvenates stem cells and counters age-related gut degeneration in mice and human models. 

Images of miniature intestines developed from intestinal stem cells. 

<p><span style="font-weight: 400;">Participants: Healthy, overweight older adults </span></p>
<p><span style="font-weight: 400;">Dosage: 6 mg/day of spermidine supplemented orally for 13 weeks </span></p>


Oxford scientists find that spermidine, a naturally occurring molecule that declines with age, rejuvenates aging immune cells and improves vaccine protection in older adults. 


Study conducted at the University of Oxford in England. 

Immunity

Duke University scientists have successfully induced new neuronal connections in the brains of mice, leading to improvements in social interaction and stress resilience. 

Search Result: stem cells

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

GlyNAC and Exercise for Age-Related Muscle Loss: Mechanisms and Clinical Evidence

Alpha-Lipoic Acid Rejuvenates Stem Cells & Improves Gut, New Study Shows

Anti-Aging Spermidine Boosts Immune System, New Study Shows

Can We Reverse Memory Loss? Duke Scientists Find New Way to Rewire the Brain