Life Biosciences reports preliminary visual-field improvements in two of three glaucoma patients treated with the experimental therapy developed by Dr. David Sinclair’s Harvard team, ER-100.

Aging &amp; Longevity

Model: 6- to 8-week-old male C57BL/6J mice
Dosage: 0.5 mg/kg of isolated mitochondria injected every two days for six injections in the tail vein

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

Transplantation of the cell’s powerhouses (mitochondria) improves heart function by restoring mitophagy (the cellular process that clears damaged mitochondria) in a mouse model of cardiac aging.

(An image depicting mitochondria [ovoid structures] in cardiac tissue | NAD.com)

Mitochondrial transplantation improves heart function by restoring the cellular process that clears damaged mitochondria in a mouse model of cardiac aging.

Cardiovascular

The Future of Longevity: Could Humans Really Live to 150?

A TIME Magazine longevity panel, featuring Harvard’s David Sinclair, explores whether breakthroughs in AI, cellular rejuvenation, and research on sex differences could help today’s children live far longer.

(An image illustrating the possibility of some humans achieving a 150-year lifespan in the future | NAD.com)

David Sinclair and Jennifer Garrison discuss whether AI advancements, cellular rejuvenation techniques, and research on sex differences can make a 150-year lifespan possible.

The Harvard geneticist discussed an early human trial, unpublished mouse results, and an AI-assisted search for chemical rejuvenation therapies on the Joe Rogan Experience. 

Model: Chronically stressed mice 
Dosage: 9 mg/kg/day of L-serine, or 5 mg/kg/day of dasatinib combined with 50 mg/kg/day of quercetin

Supplementing chronically stressed mice with L-serine, an amino acid, counters signs of anxiety and diabetes while diverting age-promoting senescent cells within the brain’s fear center. 

Search Result: stem cells

David Sinclair’s Experimental Cell-Rejuvenation Therapy Shows Early Vision Signals in First Human Trial

Mitochondrial Transplantation Rejuvenates Aging Hearts, Study Finds

The Future of Longevity: Could Humans Really Live to 150?

“Prophet of Longevity” David Sinclair Reveals New Anti-Aging Data

Cheap Supplement May Counter Stress-Induced Diabetes, Anxiety, and Brain Senescence, According to New Study