Model: C57BL/6 mice and Zpmste24-deficient progeria mice
Dosage: .03% w/w of canagliflozin mixed into diets from day 3 to 20 weeks

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Japanese scientists uncover that a diabetes drug called canagliflozin removes senescent cells and moderately extends lifespan in a mouse model of premature aging.

(A laboratory mouse alongside the molecular structure of canagliflozin | NAD.com)

The diabetes medication canagliflozin clears senescent cells and extends lifespan in a mouse model of premature aging called progeria.

Aging &amp; Longevity

Manipulating Aging Through Cutting-Edge Gene Therapies

Gene therapy techniques like CRISPR and RNA replacement compensate for or replace defective longevity-associated genes like KLOTHO or FOXO genes.

(A scientist in a laboratory performing gene therapy research)

Researchers continue to develop ways to substitute, edit, and delete gene sequences to engineer and improve the expression of certain genes related to aging.

Reviews

Cell Reprogramming: True Age Reversal Technology

A gene manipulation technique called cellular programming extends the lifespan of mice and reverses signs of aging in multiple studies, leading to large financial investments in this new technology.  


A stem cell visualized under the microscope with fluorescence. (shutterstock.com | DrimaFilm)

Model: C57BL/6J mice
Dosage: 1 mg/mL for a total of 3 mL daily of abacavir dissolved in drinking water for six months

Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging

Latent viral sequences in DNA have evolved with mutations to render them inactive, yet the most recently inherited of these lack suppression, and their activity drives aging.

(Transmission electron microscopy images of young human cells treated with medium from young cells [top] and senescent cells [bottom]. The cell on the bottom treated with senescent cell medium exhibits a dark circle that is a retrovirus-like protein.)

Viral sequences inserted into DNA during ancient viral infections can become activated as we get older, driving cellular senescence and aging.

Model: Prematurely aged (progeria) mice
Dosage: Tail vein injection of mTERT (mouse telomerase) lentiviral constructs

Using a therapy that extends telomeres — the DNA at the ends of our chromosomes, scientists reduce senescence in human cells and significantly prolong the lifespan of mice. 


Senior author, Dr. John Cooke with research team | Credit: Daniel Kramer, Houstonia 

Search Result: progeria

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Manipulating Aging through Cutting-Edge Gene Therapies

The Emergence of Cellular Reprogramming: True Age Reversal Technology

Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging

Scientists Prolong Mouse Lifespan by Extending Telomeres