Could Aging Leave a "Memory" That Spreads and Even Passes to the Next Generation?

A new aging model posits that aging imprints signatures across molecular, tissue, and organ system levels, and these signatures may also transmit across generations.

(A new theory posits that imprinted cellular signatures of aging can transmit between generations | NAD.com)

A new theory posits that aging imprints molecular-, cellular-, tissue-, and organ system-level signatures that may transmit across generations.

Aging &amp; Longevity

Stem cell therapy improves the reproductive potential of monkeys, with one aged monkey becoming pregnant.

(Image: labroots.com) Cynomolgus monkeys. 

Others

Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

An immune system enzyme called CD38 is associated with low NAD+ levels, shortened reproductive lifespan, and fertility problems in female mice.  


Immunity

Model: NAD+-deficient mice
Dosage (oral): 400 mg/kg of nicotinamide riboside (NR)

Chinese scientists enhance the fertility of middle-aged mice with nicotinamide riboside (NR) by addressing the cellular metabolic deficits associated with aging ovaries.

4-cell embryos from the ovaries of mice given NR. 

 Explore the findings of a new study revealing the potential of NR (nicotinamide riboside) in enhancing female reproductive lifespan and promoting fertility in middle age. Discover the impact of NAD (nicotinamide adenine dinucleotide) supplementation on reproductive health and the promising advancements in fertility research. Read more on NAD.

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Could Aging Leave a “Memory” That Spreads and Even Passes to the Next Generation?

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New Study Shows NR Enhances Female Reproductive Lifespan and Promotes Fertility in Middle-Age