A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

An aging research aficionado, Dr. Josh Helman, shares five supplements that can help fight the effects of aging: nitric oxide, NMN, honokiol, modified citrus pectin, and creatine.

(Harvard-trained aging expert, Dr. Josh Helman | Jupiter Medical Center)

Harvard-trained aging expert Dr. Josh Helman unveils his top five supplements to fight against aging.

Aging &amp; Longevity

Model: Wistar rats fed a high-fat diet and injected with streptozotocin to model diabetes and diabetic nephropathy
Dose (oral): 100 mg/kg honokiol, or 150 mg/kg metformin for 8 weeks

Honokiol — a molecule found in Magnolia plants — and metformin — a diabetes drug — comparably stabilize blood glucose levels, reduce inflammation, and deter kidney damage in a rat model for diabetes. 

Principal Investigator, Dr. Manish Kumar | LinkedIn

Model: male Sprague-Dawley rats
Dosage: 5 mg/kg of honokiol (injection) or 15 mg/kg icariin (oral)

NMN and Herbal Compounds Prevent Neuron Death in Parkinson’s

Scientists report that the NAD+ precursor NMN and traditional East Asian herbal compounds icariin and honokiol prevent neuron death in a cell and animal model for Parkinson’s disease. 


Magnolia flowering plant, where honokiol can be derived (Shutterstock/Nikolay Kurzenko)

Potential therapeutic modulations of Sirtuins through synthetic- and plant-derived compounds can help design new-generation cheap, non-toxic Sirtuin-based drugs against lung fibrosis.

Search Result: honokiol

A Harvard-Trained Doctor’s Top 5 Anti-Aging Supplements

Honokiol is a Potential Natural Alternative to Metformin for Diabetes and Kidney Health, Suggests Study

Study Shows NMN and Herbal Compounds Prevent Neuron Death in Parkinson’s Models

Therapeutically Targeting Sirtuins Presents Promise for Lung Fibrosis