Model: Naturally aged 24-month-old C57BL/6 mice 
Dose: 0.1 mg/kg/day of folic acid administered orally for 12 months

Supplementation with vitamin B9, also known as folic acid or folate, prevents cellular senescence and slows vascular aging in naturally aged mice.  

Cardiovascular

Scientists find that limiting folate (vitamin B9) beginning at mid-age leads to slowed aging in mice. 

Is reducing vitamin B9 intake good or bad in older age?

Aging &amp; Longevity

Model: Male Sprague Dawley Rats; 3-months-old 
Dosage: Folic Acid (FA): FA deficient diet, 0.1 mg/kg; FA Normal Diet, 2.0 mg/kg; FA Low Diet, 4.0 mg/kg; FA High Diet, 8.0 mg/kg

Taking Vitamin B9 Enhances Memory and Counters Brain Deterioration, Study Finds 

New research shows that long-term supplementation with vitamin B9 boosts memory and protects against brain deterioration in aged rats.  

Model: Older adults with varying levels of cognitive decline 
Dosage (oral): 1,700 mg DHA, 600 mg EPA, 0.5 mg B12, 1 mg B9, and 20 mg B6

Several recent studies suggest that the effectiveness of alleviating cognitive deficits with omega-3s in older adults depends on vitamin B levels. 


Search Result: folic acid

New Study: Vitamin B9 Combats Cell Senescence to Slow Vascular Aging

How Not Eating Leafy Greens Can Make You Age Slower

Taking Vitamin B9 Enhances Memory and Counters Brain Deterioration, Study Finds

How B Vitamins and Omega-3s Could Prevent Cognitive Decline