Participants: Healthy males (age range: 70-76)
Dosage: 1 mg per day of rapamycin for 8 weeks

Supplementing with rapamycin leads to improvements in cardiac and vascular function in older men, suggesting this longevity-associated drug may counteract cardiovascular aging. 

Nicolas Musi, MD, professor of medicine and an author of the study (image: sanantoniomag.com). 

Cardiovascular

Based on human evidence, Harvard and MIT scientists determine the most promising anti-aging interventions, including NAD+ precursors, spermidine, and senolytics. 


MIT’s Leonard Guarente, Ph.D. (image: amacad.org), Harvard’s David Sinclair, Ph.D. (image: buckinstitute.org), and University of Paris Descartes’ Guido Kromer, Ph.D., M.D. (image: createcures.org). 

David Sinclair and fellow top aging biology researchers review clinical trials pertaining to the eight anti-aging compounds. 

Aging &amp; Longevity

The story behind how the most scientifically-backed life-extending agent — rapamycin — was accidentally discovered on the world’s most isolated body of land inhabited by humans, Rapa Nui, a.k.a. Easter Island.

Easter Island’s world-famous moai monoliths. | (shutterstock.com | Stefano73)

Model: C57BL/6 mice
Dose &amp; Administration: 14 mg/kg rapamycin, 1000 mg/kg acarbose and phenlbutryate mixed in chow

Study Identifies New Age-Reversing Drug Cocktail 

A cocktail of rapamycin, acarbose, and phenylbutyrate reduces fat, improves learning, and enhances strength and endurance in aged mice. 

Age Reversed Kidney Tissue | Jiang et al., 2022 | Scientific Reports 

Search Result: everolimus

Longevity Drug Rapamycin Improves the Heart of Older Adults, New Study Shows

David Sinclair and Colleagues Summarize 8 Anti-Aging Medicines Applicable to Humans

Most Powerful Life-Extending Agent To-Date Discovered in Ancient Volcano Crater

University of Washington Study Identifies New Age-Reversing Drug Cocktail