<ul>
<li style="font-weight: 400;" aria-level="1">The monkeys used in the study, including eight young ones (4–6 years old, four females and four males) and eight aged ones (18–21 years old, four females and four males), were originally from Southeast Asia.</li>
<li style="font-weight: 400;" aria-level="1">Three groups of male C57BL6/J mice: young-lenti-Luc (2-month-old), aged-lenti-Luc (24-month-old) and aged-lenti-SIRT2 (24-month-old).</li>
<li style="font-weight: 400;" aria-level="1">hiPSC derived CMs</li>
</ul>

New Study Reveals Activating Sirtuins Could Reverse Heart Aging 

Researchers have identified a sirtuin (SIRT2) as a therapeutic target for age-related cardiovascular disease.

Cardiovascular

Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

Mixing nutraceutical molecules with nicotinamide adenine dinucleotide (NAD+) precursors may synergistically boost and maintain NAD+ levels while bolstering their longevity-promoting benefits.

(An aged individual’s hand alongside a younger person’s hand, each holding different types of supplement capsules | NAD.com)

Combining nutraceuticals with NAD+ precursors may be a potent way to boost and maintain NAD+ levels while promoting other anti-aging benefits.

Reviews

NAD+ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Aging &amp; Longevity

Senolytics: Clearing Troublesome Senescent Cells for Revitalized Aging

Senolytics selectively eliminate senescent cells — non-proliferative cells that release inflammatory molecules to surrounding tissue triggering otherwise healthy cells to enter senescence.

Senolytics, including dasatinib and quercetin along with fisetin, selectively eliminate aged, non-proliferative cells (senescent cells) to revitalize organ health and alleviate age-associated diseases.

Model: Male C57BL/6 mice injected with D-galactose to accelerate aging 
Dose: 100 mg/kg aminoguanidine or 40 mg/kg resveratrol injections

Resveratrol — a naturally occurring anti-aging compound — preserves kidney structure, prevents dysfunction, and quenches harmful senescent cells in age-accelerated mice. 

Abstract depiction of scientist holding a microscope slide with kidney sample (generated by Midjourney).

Search Result: cardiac fibrosis

New Study Reveals Activating Sirtuins Could Reverse Heart Aging

Enhancing Longevity-Promoting Cocktails: Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Senolytics: Clearing Troublesome Senescent Cells for Body Revitalization

Taiwanese Study Reveals Resveratrol’s Remarkable Role in Kidney Health and Senescent Cell Reduction