Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Aging &amp; Longevity

A potentially transformative antibody that inhibits the IL-11 protein increases mouse lifespan by 22% by targeting the same pathways as metformin and rapamycin. 

Antibody prolongs the lifespan of mice by 22%. 

The large-scale preclinical study shows that SRN-901 significantly extends lifespan and healthspan while improving a great number of aging parameters.


Seragon Biosciences increases the lifespan and healthspan of mice in one of the largest studies of its kind. 

Model: HET3 mice, which are genetically heterogenous to model the diversity of human genetics more precisely than other lab mice, which are usually genetically homogenous 
Dosage: 67% reduction in dietary intake of isoleucine

Limiting dietary intake of the amino acid — protein building block — isoleucine significantly extends the lifespan of male mice and modestly extends the lifespan of female mice. 


Model: Male C57BL/6 J 
Dosage: 5 mM spermidine in drinking water

Supplementing aged and young mice with spermidine increases muscle blood vessel growth and blood flow, implying improved cardiovascular health and exercise performance. 


Corresponding investigator Koji Ikeda, M.D., Ph.D. | Research Gate 

Search Result: Tumor incidence

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

Anti-Aging Antibody Significantly Extends Life by 22% in Breakthrough Study

Seragon’s Aging Intervention Drug SRN-901 Achieves One of the Largest Extensions of Lifespan and Healthspan to Date

Study Shows Avoiding Consumption of Protein Building Block Isoleucine Increases Lifespan

Latest Study Shows Spermidine Significantly Boosts Blood Flow & Promotes Cardiovascular Health