Model: C57BL/6N male mice 
Dosage: AIN-93 M diet with 0.025% (15 mg/kg per day) niclosamide for the Old + NL group or 0.050% (30 mg/kg per day) niclosamide for the Old + NH group, starting at 12 months of age to 21 months of age

Drug Approved Against Tapeworms May Counteract Aging, Suggests New Study

New research suggests niclosamide, approved for human use against tapeworms, alleviates frailty and suppresses the protein complex mTOR, which regulates cell growth, in aged mice.

(The drug niclosamide | Hospital Pharmacy Europe)

Niclosamide, an agent approved for human use against tapeworms, alleviates age-related frailty, suppresses mTOR, and activates autophagy in old mice.

Aging &amp; Longevity

The NAD+-consuming enzyme CD38 is elevated in individuals predisposed to Alzheimer’s, and blocking it improves the metabolic health and cognition of mice that model Alzheimer’s. 


Principal investigator Michal Shwartz, PhD (Image: Jonathan Bloom).

Brain &amp; Neurons

Pioneering expert in NAD+ metabolism, Shin-Ichiro Imai, MD, PhD, explains the critical role of NAD+ in preventing chronic kidney disease, the ninth leading cause of death worldwide. 


Dr. Shin-Ichiro Imai (image: mspremium.com)

Model: 24-month-old male and female C57BL/6J mice
Dosage: 3 mg/kg/day, delivered continuously over 8 weeks

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Scientists show that elamipretide restores muscle and heart function in aging mice but doesn’t affect epigenetic or transcriptomic age.


Cardiovascular

Model: Naturally aged C57BL/6J mice

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

A new study provides data suggesting compromised intestinal function with age and that fasting for short periods promotes intestinal regeneration and function in aged mice.

(A dysfunctional intestinal barrier that leaks harmful substances and bacteria into circulation develops with age | The Amino Company)

Alternate-day fasting, a form of intermittent fasting, reverses age-related intestinal barrier leakage in old mice.

Search Result: Organ aging

Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study

Blocking NAD+ Breakdown Improves Brain Fitness and Cognition, New Study Shows

Expert Explains Role of NAD+ in Preventing Age-Related Kidney Disease

Diabetes Drug Elamipretide Reverses Muscle and Heart Aging: New Study Reveals

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So