Model: Male 16-month-old C57BL/6 mice 
Dosage: Intraperitoneal injection of 20 mg/kg/day of inosine for 4 weeks

Inosine Supplment Combats New Driver of Aging 

Scientists discover that inosine—a type of molecule called a purine nucleoside—alleviates multiple-organ aging in mice, and restores the oxygen delivery capacity of red blood cells. 


An artistic depiction of red blood cells delivering oxygen to surrounding tissues. 

Aging &amp; Longevity

Aging Guru Bryan Johnson’s Supplement List for 2026

Changes to Bryan Johnson’s latest supplement stack include taking NMN or NR six days a week, rather than seven, and eliminating the use of rapamycin.

(Bryan Johnson, who utilizes a continuously updated protocol to slow aging and optimize his body | Netflix)

Changes to Bryan Johnson’s updated 2026 supplement stack include taking NMN or NR six days a week instead of seven and removing rapamycin.

Model: 11-month-old male C57BL/6J mice 
Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Brain &amp; Neurons

NAD+ Ranked #2 Most Powerful Anti-Aging Agent

Based on current scientific evidence, Dutch researchers have ranked existing anti-aging interventions based on how likely they are to protect against DNA damage and aging. 


On the far right, one of the researchers, Dr. Jan H.J. Hoeijmakers (image: amazinggerasmusmc.nl). 

DNA Repair

Model: 20-month-old male C57BL/6 mice 
Dosage: 3,000 to 4,000 µg of ouabain dissolved in 27,000 to 36,000 µL of PBS injected twice per week every third week over a period of three months

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions

Harvard and MIT scientists analyze decades of publicly available molecular studies with a new AI platform to uncover hundreds of previously hidden anti-aging strategies, like the drug ouabain.

A new AI platform has uncovered hundreds of pro-longevity agents based on the reanalysis of millions of mouse and human gene expression samples.

Search Result: Nicotinamide Riboside

Inosine Supplment Counters New Driver of Aging

Aging Guru Bryan Johnson’s Supplement List for 2026

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study

NAD+ Ranked #2 Most Powerful Way to Reverse DNA Damage & Aging

AI Analyzes Millions of Molecular Profiles to Uncover Overlooked Aging Interventions