Participants: Adults over the age of 60
Dosage: 3,750 mg of niacin twice daily (after gradual dose increase), 150 mg of dihydroberberine twice daily, 50 mg of taxifolin (with 500 mg of vitamin C and 15 mg of zinc) twice daily, 50 mg of tocotrienols twice daily

A combination of supplements, including the NAD+ precursor nicotinic acid, improves cholesterol, allowing some participants to cease taking statins.  

Study conducted by Professor Emeritus Joseph Keenan, MD, at the University of Minnesota. 

Nicotinic Acid

Model: Male ApoE−/− mice fed a high-fat diet for 12 weeks to induce atherosclerosis.
Dosage: Methyl-β-cyclodextrin (Mß-CD) at 2.0 g/kg, subcutaneous injection, twice a week

 A new study shows cyclodextrin reduces artery plaques in mice by lowering cholesterol and blocking inflammatory cell death. 

Cardiovascular

Participants: Healthy middle-aged to older adults (average age: ~53 years)
Dosage: 1,000 mg/day of urolithin A for 28 days

Supplementing healthy adults with urolithin A —a compound produced by our gut bacteria— counters signs of age-related immune system decline.  

Principal investigator Dr. Florian R. Greten (image: hessen-schafft-wissen.de).

Immunity

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

According to French scientists, no organ system appears as vulnerable to aging as the cardiovascular system, and anti-aging therapeutics may help mitigate the effects of cardiovascular disease.

(The principal investigator behind the review, aging researcher Guido Kroemer | Olympiad in Cardiovascular Medicine)

Anti-aging therapeutics may prevent and slow age-related cardiovascular dysfunction.

University of California (UC) Berkeley scientists moderately extend the lifespan of old mice by giving them oxytocin (sometimes called the "love hormone") and a compound that inhibits inflammation.  

Search Result: NAD Therapy

NAD+ Boosting Supplement Challenges Cholesterol-Lowering Statins in Anti-Aging Research

Scientists Find a New Way to Stop Dangerous Artery Plaques From Growing

Urolithin Supplement Counters Immune System Aging, New Human Trial Shows

The Latest Insight on Anti-Aging Therapeutics Targeting Cardiovascular Disease

New UC Berkeley Study: “Love Hormone” and Anti-Inflammatory Combo Extend Life