Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

Scientists cure type 2 diabetes by replicating the function of the pancreas with stem cells. 


Diabetes &amp; Obesity

Senolytics: Clearing Troublesome Senescent Cells for Revitalized Aging

Senolytics selectively eliminate senescent cells — non-proliferative cells that release inflammatory molecules to surrounding tissue triggering otherwise healthy cells to enter senescence.

Senolytics, including dasatinib and quercetin along with fisetin, selectively eliminate aged, non-proliferative cells (senescent cells) to revitalize organ health and alleviate age-associated diseases.

Model: C57BL/6J Mice
Dosage: 20 ug of sEVs’ protein on days 1 and 14 of experiment

Particles Secreted from Stem Cells Significantly Reduce Aging

University of Valencia researchers use small vesicles (sEVs) derived from young stem cells (ADSC) to reduce frailty, regulate inflammation, and lower senescence - a critical dormant state of cell-cycle arrest that drives aging. 


Senior author, Dr. Consuelo Borras | INCLIVA

University of Valencia researchers use small vesicles (sEVs) derived from young stem cells (ADSC) to reduce frailty, regulate inflammation, and lower senescence - a critical dormant state of cell-cycle arrest that drives aging. 

5 mg/kg Dasatinib
50 mg/kg Quercetin

Senolytics Restore Muscle Building Potential in Old Age 

Scientists find that the combination of Dasatinib and Quercetin blocks age-related resistance to muscle growth in old mice and eliminates senescence cells in mouse and human muscle.

Search Result: Kidney transplantation

Top Evidence-Based Interventions to Lower Biological Age

2024 Research Breakthrough: Can Stem Cells Cure Diabetes?

Senolytics: Clearing Troublesome Senescent Cells for Body Revitalization

New Study Shows Particles Secreted from Stem Cells Significantly Reduce Aging

Study Shows Senolytics Restore Muscle Building Potential in Old Mice