A description of inflammaging and related anti-aging strategies. 


Dr. Claudio Franceschi, the man who coined the term inflammaging (image: u-bordeaux.fr)

Immunity

Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Aging &amp; Longevity

Model: Naturally aged C57BL/6J mice

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

A new study provides data suggesting compromised intestinal function with age and that fasting for short periods promotes intestinal regeneration and function in aged mice.

(A dysfunctional intestinal barrier that leaks harmful substances and bacteria into circulation develops with age | The Amino Company)

Alternate-day fasting, a form of intermittent fasting, reverses age-related intestinal barrier leakage in old mice.

Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Brain &amp; Neurons

Aside from diet and exercise, senolytics — compounds that remove age-promoting cells — may rejuvenate the immune system and reduce the risk of neurodegeneration and dementia. 

Search Result: Inflammaging

What Is Inflammaging? And How to Reverse It

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Can Intermittent Fasting Slow Down Gut Aging? New Research Suggests So

Age-Reversal Tech Protects Against Neurodegeneration in Latest David Sinclair Study

Scientists Reveal How to Slow Brain Aging with Senolytics