NAD+ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Nicotinamide adenine dinucleotide (NAD+) levels decline with age, which has been linked to age-related conditions, yet NAD+-boosting precursors replenish this essential molecule.

Maximizing NAD+ levels with the precursors tryptophan, nicotinic acid, nicotinamide, NMN, or NR can alleviate age-associated diseases like cardiovascular ailments and neurodegenerative conditions.

Aging &amp; Longevity

Model: 22-month-old mice 
Dosage: Approximately 100 mg/kg/day D-serine in drinking water

The amino acid D-serine is reduced in older individuals, and D-serine supplementation improves the memory of aged mice. 


The hypothalamus of the brain controls many whole-organism functions. | shutterstock.com

Brain &amp; Neurons

Model: 24-month-old C57BL/6J mice 
Dosage: Nicotinamide riboside (12 mM) in water. Weight/body weight concentration not given

Scientists discover that NAD+ declines with age in the olfactory bulb — the brain region involved in sense of smell — and restore smell loss with NAD+ booster nicotinamide riboside in old mice. 


Lead author, Dr. Xiuli Dan | National Institute of Health (NIH)

Model: 30-month-old female New Zealand White rabbits 
Dosage: 2% cholesterol for high-cholesterol diet, 10% saturated fat (coconut oil) and 30% fructose for high-fat, high-fructose diet.

High-Fructose Diet Triggers Alzheimer's 

Aged rabbits fed a high-fructose or high-cholesterol diet exhibit features of Alzheimer’s disease, including impaired memory and amyloid-beta accumulation in the brain. 


 Lead author, Dr. Craig Weiss | Northwestern University 

Sirtuins, Lifespan Extension, and Aging

Sirtuins are a family of seven enzymes found in every cell that participate in several critical biological processes known to counter aging, like cellular energy optimization and DNA repair.

Search Result: Hypothalamus

NAD⁺ Precursors: Unlocking the Fountain of Youth by Maximizing NAD+ Levels

Brain Aging Can be Prevented by Memory-Boosting D-serine Supplement, Chinese Study Suggests

National Institute on Aging Scientists Restore Age-Related Smell Loss with NAD⁺ Booster

Northwestern University Researchers Trigger Alzheimer’s with High-Fructose Diet

Sirtuins, NAD⁺, Lifespan Extension, and Aging