New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Fayoum University researchers found that cranberry polyphenols improve metabolic markers, cognition, and oxidative stress to the same degree as the drug metformin.

A new study suggests cranberry extract has effects against aging that rival metformin.

Aging &amp; Longevity

Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

Mixing nutraceutical molecules with nicotinamide adenine dinucleotide (NAD+) precursors may synergistically boost and maintain NAD+ levels while bolstering their longevity-promoting benefits.

(An aged individual’s hand alongside a younger person’s hand, each holding different types of supplement capsules | NAD.com)

Combining nutraceuticals with NAD+ precursors may be a potent way to boost and maintain NAD+ levels while promoting other anti-aging benefits.

Reviews

Model: C57BL/6 mice
Dosage (oral): 100 mg/kg of fisetin, or 5 mg/kg of dasatinib plus 50 mg/kg of quercetin

Scientists find that when administered at a young age, the senolytic dasatinib plus quercetin (D+Q) has pro-aging effects in females, and the senolytic fisetin has anti-aging effects in males. 


Principal Investigator Dr. Erin Hascup (center) and her team. | Southern Illinois University School of Medicine 

Discover the findings from a groundbreaking study that reveals the optimal time to start senolytic supplementation for maximum anti-aging benefits. Explore the potential of senolytics in promoting healthy aging and enhancing longevity.

Study Suggests Optimal Time to Begin Senolytic Supplementation to Maximize Anti-Aging Benefits

Sirtuins, Lifespan Extension, and Aging

Sirtuins are a family of seven enzymes found in every cell that participate in several critical biological processes known to counter aging, like cellular energy optimization and DNA repair.

Basic Research

Model: D-gal artificially-aged mice
Dosage: 25 mg/kg intraperitoneal injections of C3G twice a week for 4 weeks

Plant Pigment Reduces Age-Related Inflammation and Boosts NAD+ 

The pigment cyanidin-3-O-glucoside (C3G) reduces inflammatory markers and boosts NAD+ in a mouse model for aging while reducing senescence in a cell model for aging. 

(Elderberries contain abundant cyanidin-3-O-glucoside | Jaye Thompson)

Search Result: Flavonoids

New Study Shows Cranberry Extract Equivalent to Metformin in Fighting Aging

Enhancing Longevity-Promoting Cocktails: Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

Study Suggests Optimal Age to Begin Senolytic Supplementation to Maximize Anti-Aging Benefits

Sirtuins, NAD⁺, Lifespan Extension, and Aging

Researchers find Plant Pigment that Reduces Age-Related Inflammation and Boosts NAD⁺