Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

Mixing nutraceutical molecules with nicotinamide adenine dinucleotide (NAD+) precursors may synergistically boost and maintain NAD+ levels while bolstering their longevity-promoting benefits.

(An aged individual’s hand alongside a younger person’s hand, each holding different types of supplement capsules | NAD.com)

Combining nutraceuticals with NAD+ precursors may be a potent way to boost and maintain NAD+ levels while promoting other anti-aging benefits.

Reviews

Model: C57BL/6 mice
Dosage (oral): 100 mg/kg of fisetin, or 5 mg/kg of dasatinib plus 50 mg/kg of quercetin

Scientists find that when administered at a young age, the senolytic dasatinib plus quercetin (D+Q) has pro-aging effects in females, and the senolytic fisetin has anti-aging effects in males. 


Principal Investigator Dr. Erin Hascup (center) and her team. | Southern Illinois University School of Medicine 

Discover the findings from a groundbreaking study that reveals the optimal time to start senolytic supplementation for maximum anti-aging benefits. Explore the potential of senolytics in promoting healthy aging and enhancing longevity.

Study Suggests Optimal Time to Begin Senolytic Supplementation to Maximize Anti-Aging Benefits

Aging &amp; Longevity

Sirtuins, Lifespan Extension, and Aging

Sirtuins are a family of seven enzymes found in every cell that participate in several critical biological processes known to counter aging, like cellular energy optimization and DNA repair.

Basic Research

Model: D-gal artificially-aged mice
Dosage: 25 mg/kg intraperitoneal injections of C3G twice a week for 4 weeks

Plant Pigment Reduces Age-Related Inflammation and Boosts NAD+ 

The pigment cyanidin-3-O-glucoside (C3G) reduces inflammatory markers and boosts NAD+ in a mouse model for aging while reducing senescence in a cell model for aging. 

(Elderberries contain abundant cyanidin-3-O-glucoside | Jaye Thompson)

Boosting NAD+ Improves Features of Muscular Dystrophy 

French scientists find that by inhibiting CD38 – an enzyme that breaks down NAD+ – in a mouse model for Duchene muscular dystrophy, heart and muscle function can be improved.


Search Result: Flavonoids

Enhancing Longevity-Promoting Cocktails: Combining Micronutrients with NAD+ Precursors to Maximize Their Effects

Study Suggests Optimal Age to Begin Senolytic Supplementation to Maximize Anti-Aging Benefits

Sirtuins, NAD⁺, Lifespan Extension, and Aging

Researchers find Plant Pigment that Reduces Age-Related Inflammation and Boosts NAD⁺

Blocking NAD⁺ Degradation Improves Heart and Muscle Function in Duchenne Muscular Dystrophy