Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

The XPrize Healthspan—which will split $101 million among teams developing therapeutics to restore muscle, cognitive, and immune function in older adults—has named 10 teams receiving $1 million each.

(XPrize announced the finalists for its XPrize Healthspan competition | XPrize)

The XPrize Healthspan competition has named its top 20 finalist groups that will submit their aging intervention therapies for human trial testing.

Aging &amp; Longevity

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<p data-start="97" data-end="197">Model: Aged mice (18 months old, C57BL/6 strain) and aged rhesus macaques (18–21 years old).</p>
<p data-start="97" data-end="197">Dosage: Mice received 100 µg of EVs^ABPC via tail vein injection twice per week for 4 weeks.<br data-start="297" data-end="300" data-is-only-node="" />Rhesus macaques received 200 µg/kg of EVs^ABPC intravenously once per week for 20 weeks.</p>
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Scientists Discover Deer Antler Stem Cells That Reverse Aging in Mice and Monkeys

Researchers discover that deer antler stem cells can restore bone density, slow aging, and reverse biological age in mice and primates.

<p>Model: 5xFAD mice</p>
<p>Dosage: 5-µL sprayed into each nostril at concentrations of 30 × 109/100 µL once weekly for two weeks</p>


Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Researchers use nano-sized vesicles derived from neural stem cells to preserve cognition as well as reduce brain inflammation and plaque buildup in an Alzheimer’s mouse model.

(An aged woman using an intranasal spray to avert Alzheimer's disease progression | NAD.com)

Brain &amp; Neurons

Bryan Johnson Injects 300 Million Stem Cells in Latest Longevity Ploy

Bryan Johnson traveled to Cell Colabs in the Bahamas to inject his major joints with 300 million stem cells for enhanced performance and longevity. 

<p>Model: 5XFAD transgenic mouse model for Alzheimer&#8217;s disease </p>
<p>Dosage: Intravenous administration of 200 μl extracellular vesicles (0.5 μg/μl concentration) </p>


 Particles secreted from stem cells called extracellular vesicles (EVs) counter memory loss and neurodegeneration in an Alzheimer’s disease mouse model.  


Principal Investigator Dr. Jialin Zheng | Tongji University School of Medicine 

Search Result: Extracellular vesicles

10 Finalist Teams Awarded $1 Million in XPrize Healthspan Contest to Transform Healthy Aging

Scientists Discover Deer Antler Stem Cells That Reverse Aging in Mice and Monkeys

Exploring a Nasal Spray that Might Delay Alzheimer’s Progression by Years

Bryan Johnson Injects 300 Million Stem Cells in Latest Longevity Ploy

Study Shows Stem Cell-Secreted Particles Can Reverse Alzheimer’s