Aging Guru Bryan Johnson’s Supplement List for 2026

Changes to Bryan Johnson’s latest supplement stack include taking NMN or NR six days a week, rather than seven, and eliminating the use of rapamycin.

(Bryan Johnson, who utilizes a continuously updated protocol to slow aging and optimize his body | Netflix)

Changes to Bryan Johnson’s updated 2026 supplement stack include taking NMN or NR six days a week instead of seven and removing rapamycin.

Aging &amp; Longevity

Dark Chocolate Compound Linked to Slower Aging, Study Finds

Elevated circulating theobromine—derived from cocoa—was associated with a slower pace of aging, according to two assessments.

(The molecular structure of theobromine | Forbes)

A compound derived from dark chocolate, theobromine, circulating at higher levels, is associated with a reduced pace of aging.

Epigenetics

Model: UM-HET3 Mice 
Dosage: 0, 75, 150, 300, 600, and 1200 ng epicatechin/mg food; 0, 0.075, 0.15, 0.3, 0.6, and 1.2 ng halofuginone/mg food; and 0, 37.5, 75, 150, 300, and 600 ng mitoglitazone/mg food, all given ad libitum in food starting at seven months old

Three Compounds Show Promise for Male Longevity

Data from a rigorous longevity study show promise for three new compounds, adding to the repertoire of mouse lifespan-extending substances.

(The three compounds’ effects on median lifespan extension | Rapamycin Longevity News)

The world’s most rigorous longevity study presents data showing promise for three new lifespan-extending compounds in male mice.

An Ordinary Guy Tries Bryan Johnson’s Blueprint Longevity Routine

Podcaster Nick Tucker tries Bryan Johnson’s Blueprint longevity protocol for a month and reverses his biological age — a prediction of how long you have left.

(Hard Reset podcaster Nick Tucker [left] alongside longevity guru Bryan Johnson [right] | freethink.com)

Undergoing Bryan Johnson’s Blueprint protocol — an overhaul of supplementation, diet, and exercise — propelled age-reversing effects for the podcaster Nick Tucker.

Model: Wistar rats 
Dosage: 4 g/kg grapeseed flour

Feeding rats large amounts of grapeseed flour significantly increases their lifespan and elevates their NAD+/NADH ratio — an indicator of optimized NAD+ metabolism — in multiple organs. 


Grapes and grapeseed flour | Image: Originally Africa (not a sponsor of this study)

Search Result: Dark chocolate

Aging Guru Bryan Johnson’s Supplement List for 2026

Dark Chocolate Compound Linked to Slower Aging, Study Finds

Three Compounds Show Promise for Male Longevity

An Ordinary Guy Tries Bryan Johnson’s Blueprint Longevity Routine

Study Reveals Surprising Benefits of Grapeseed Flour: Increased Lifespan and Multi-Organ NAD+ Rejuvenation