Model: Male C57BL/6 mice injected with D-galactose to accelerate aging 
Dose: 100 mg/kg aminoguanidine or 40 mg/kg resveratrol injections

Resveratrol — a naturally occurring anti-aging compound — preserves kidney structure, prevents dysfunction, and quenches harmful senescent cells in age-accelerated mice. 

Abstract depiction of scientist holding a microscope slide with kidney sample (generated by Midjourney).

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Model: C57BL/6J male mice
Dosage: 500 mg/kg/day of NMN and 435 mg/kg/day of NR intraperitoneally injected for four consecutive days beginning two hours before cisplatin-induced kidney injury

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Supplementing with nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) confers comparable benefits against kidney disease in male mice.

(The study’s principal investigator, Dr. Katalin Susztak, MD, PhD | Emory Daily Pulse)

NMN and NR have similar effects in reducing molecular markers for kidney dysfunction in a mouse model for kidney disease.

Nature Aging study reveals light-dependent technique to more accurately eliminate senescent age-associated cells and counter signs of brain, muscle, kidney, and liver aging in old mice. 

Light-Sensitive Smart Senolytic KSL0608-Se 

An orally available NAD+ precursor NR relieves acute kidney injury but not chronic kidney disease.

NR ameliorates the effects of acute kidney disease but does not relieve chronic kidney disease.

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Taiwanese Study Reveals Resveratrol’s Remarkable Role in Kidney Health and Senescent Cell Reduction

Latest UPenn Study Reveals NMN and NR Have Similar Efficacy in a Kidney Disease Model

Researchers Counteract Liver, Kidney, and Muscle Aging with Light-Activated “Smart” Senolytic

NR Supplementation Alleviates Kidney Disease in Mice for the Short-Term