Dr. Sinclair and collaborators show that an age-reversal technology that rejuvenates cells protects neurons from inflammation and cell death in mice. 

Brain &amp; Neurons

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Participants: Physically active and healthy older adults 
Dosage: 1 gram of omega-3s (330 mg EPA plus 660 mg DHA) per day, 2,000 IU of vitamin D per day, and 30 minutes of strength training exercises three times per week

While omega-3 supplementation slows biological aging, adding vitamin D and exercise further slows biological aging.

The “father of aging clocks” and senior study author Steve Horvath, PhD, of Harvard University (Image: quantamagazine.org). 

Aging &amp; Longevity

The Dementia Surge: New Study Projects Cases to Double by 2060

Researchers project dementia cases in the U.S. to double by 2060, revealing higher incidence in women, Black adults, and APOE ε4 carriers

Aside from diet and exercise, senolytics — compounds that remove age-promoting cells — may rejuvenate the immune system and reduce the risk of neurodegeneration and dementia. 

Search Result: Clinical Trials

Age-Reversal Tech Protects Against Neurodegeneration in Latest David Sinclair Study

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging

The Dementia Surge: New Study Projects Cases to Double by 2060

How Does the Immune System Affect the Brain? Scientists Reveal How to Slow Brain Aging