A vaccine targeting an enzyme that breaks down NAD+, called CD38, counteracts signs of aging in mice. 


Immunity

The UN’s Brief on the Biology of Aging

A new brief from the United Nations (UN) Scientific Advisory Board examines the latest developments in geroscience—a field devoted to delaying, preventing, and treating diseases linked to aging.

A new United Nations brief examines how researchers are addressing an aging global population with geroscience—a field seeking to understand how to intervene against aging.

Aging &amp; Longevity

Model: 27-month-old male C57BL/6N mice 
Dosage: 50 mg/kg/day of fisetin for 1 week, followed by no treatment for 2 weeks, followed by another week of treatment

Plant-based molecule fisetin preserves muscle mass and strength in older mice via senolytic action — removal of senescent (dysfunctional) cells.


Study conducted at the University of Colorado Boulder (image: govtech.com) 

Skin &amp; Muscle

Participants: Werner syndrome patients 
Dosage: 1 gram of NR per day for 26 weeks

The NAD+ (nicotinamide adenine dinucleotide) booster NR (nicotinamide riboside) improves cardiovascular health in Werner syndrome patients. 

A child with Werner syndrome (image: britannica.com)

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age

A new human study shows that a procedure involving the replacement of blood plasma with a fresh solution (therapeutic plasma exchange) lowers a measure of how quickly the body is aging (biological age).

(The Buck Institute for Research on Aging | Facebook)

In a first-of-its-kind human trial, participants who underwent therapeutic plasma exchange exhibited significantly lowered biological age.

Search Result: Cardiovascular Disease

Anti-Aging Vaccine Boosts Strength, Memory & NAD+ in New Study

The UN’s Brief on the Biology of Aging

Fisetin Fights Frailty: New Study Shows Supplment Preserves Strength

NAD+ Precursor NR Improves Heart Health in People with Accelerated Aging, New Study Shows

Latest Human Trial from the Buck Institute Shows Plasma Exchange Lowers Biological Age