Model: UM-HET3 mice and 5XFAD mice 
Dosage: UM=HET3 mice received 180 mg/kg canagliflozin in chow starting at seven months of age, and FXFAD mice received 180 mg/kg canagliflozin in chow beginning at three months of age

New Study: Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression

The diabetes drug canagliflozin improves learning and memory in middle-aged male mice and reduces brain plaques in Alzheimer’s model mice.

The FDA-approved diabetes medication canagliflozin improves cognition in a mouse model of Alzheimer’s disease in males only.

Brain &amp; Neurons

Model: C57BL/6 mice and Zpmste24-deficient progeria mice
Dosage: .03% w/w of canagliflozin mixed into diets from day 3 to 20 weeks

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Japanese scientists uncover that a diabetes drug called canagliflozin removes senescent cells and moderately extends lifespan in a mouse model of premature aging.

(A laboratory mouse alongside the molecular structure of canagliflozin | NAD.com)

The diabetes medication canagliflozin clears senescent cells and extends lifespan in a mouse model of premature aging called progeria.

Aging &amp; Longevity

Model: UM-HET3 mice
Dosage: Astaxanthin was fed at 4,000 ppm in the diet beginning after weaning
Meclizine was fed at 800 ppm in the diet beginning after weaning
Administering fisetin started at 20 months old and was fed continuously or a repeated cycle of three days on and 11 days off at a target of 600 ppm in the diet

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

A consortium that examines longevity interventions in mice has found that the anti-nausea compound meclizine as well as the antioxidant astaxanthin extend male mouse lifespan.

(A long-lived mouse surrounded by potential lifespan-extending compounds | NAD.com)

A consortium of researchers has identified the anti-seasickness drug meclizine and the antioxidant astaxanthin as two compounds that significantly extend male mouse lifespan.

Metabolic Regulators: Improving Energy Production and Expenditure

Metabolic modulators like rapamycin, urolithin A, acarbose, glycine and N-acetyl cysteine, and canagliflozin enhance mitochondrial function to improve metabolism to increase longevity.

(A mitochondria surrounded by a canagliflozin molecule [top left], an acarbose molecule [bottom left], and an N-acetyl cysteine molecule [bottom right])

Explore the impact of metabolic regulators on energy production and expenditure. Discover how these regulators influence cellular metabolism and potentially contribute to improved energy balance and overall health at NAD.com.

Search Result: Canagliflozin

Diabetes Medication Improves Cognition and Alleviates Alzheimer’s Progression, Suggests New Study

Japanese Study: Common Diabetes Drug Clears Senescent Cells and Extends Lifespan

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

Metabolic Regulators: Extending Lifespan by Modulating Energy Production and Mitigating Cell Damage