New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

A new gene network-based framework predicts the potential of existing drugs to confer pro-longevity effects.

A new gene network-based framework predicts already-approved repurposable drugs that may either confer pro-longevity benefits or age-accelerating effects.

Aging &amp; Longevity

<p><span style="font-weight: 400;">Model: SAMP8 mice </span></p>
<p><span style="font-weight: 400;">Dosage: ~25 mg/kg/day of PQQ or PQI administered in food </span></p>


Supplementing with the antioxidant pyrroloquinoline quinone (PQQ) modestly extends the lifespan of age-accelerated mice while improving their strength.  


The chemical structure of pyrroloquinoline quinone (image: skintypesolutions.com).

Examining Evidence for the Cognition-Enhancing Potential of the Antioxidant Astaxanthin

The antioxidant astaxanthin significantly extends male mouse lifespan, and human research suggests it may help prevent age-related cognitive decline.

(An image of the red-orange pigment astaxanthin | Gruppo Farmalmpresa)

The potent antioxidant astaxanthin may have pro-longevity effects, and human trial data suggests it improves cognitive function in older adults.

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<p class="PDq2pG_selectionAnchorContainer" data-start="0" data-end="125">Model: 4-week-old <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">SM/J</span></span> mice (with <span class="hover:entity-accent entity-underline inline cursor-pointer align-baseline"><span class="whitespace-normal">C57BL/6J</span></span> comparison mice)</p>
<p data-start="127" data-end="279" data-is-last-node="" data-is-only-node="">Dosage: Weekly intraperitoneal injections of 40 mg/kg Navitoclax or 5 mg/kg Dasatinib + 50 mg/kg Quercetin from 4 to 6–8 or 17 weeks of age.</p>
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Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Researchers find that clearing senescent cells preserves disc structure and slows early-onset disc degeneration in mice.


<p><strong data-start="26" data-end="36">Model:</strong> Older adults (60–85 years old) with mild cognitive impairment (MCI) enrolled in a randomized, double-blind, placebo-controlled clinical trial.</p>
<p><strong data-start="222" data-end="233">Dosage:</strong> Participants received one gastro-resistant capsule daily for 180 days, containing either 250 mg of <em data-start="339" data-end="363">Kluyveromyces fragilis</em> yeast extract, 350 mg of <em data-start="393" data-end="419">Saccharomyces cerevisiae</em> yeast extract, or a placebo.</p>


Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment

Daily supplementation with nucleotide-rich yeast extracts improves cognitive performance and mental well-being in older adults with mild cognitive impairment, researchers find. 

Search Result: Aging

New Framework Uncovers 21 Existing Drugs with Pro-Longevity Potential

Powerful Antioxidant PQQ Extends Life and Improves Strength, New Study Shows

Examining Evidence for the Cognition-Enhancing Potential of the Antioxidant Astaxanthin

Dasatinib and Quercetin Delay Early-Onset Disc Degeneration in Mice

Yeast Supplement Improves Cognitive Function in Older Adults with Mild Cognitive Impairment