Aside from diet and exercise, senolytics — compounds that remove age-promoting cells — may rejuvenate the immune system and reduce the risk of neurodegeneration and dementia. 

Brain &amp; Neurons

Columbia University scientists find that senolytics — compounds that remove age-promoting cells — restore hair follicle regeneration in a human cell/mouse model. 

Skin &amp; Muscle

A molecule found in the plasma of exercised mice reverses the brain aging of sedentary mice. 

(Image: UCSF.edu) Senior author Saul Villeda, PhD. 

Model: 40 aged patients with COPD with an average age of 71.9 
Dosage: One gram of NR taken twice daily for a total of two grams per day for six weeks

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Taking nicotinamide riboside (NR) is tied to a 52.6% reduction of an inflammatory protein in the sputum—mucus coughed up from the respiratory tract—of patients with chronic obstructive pulmonary disease (COPD).

(Principal investigator Dr. Morten Scheibye-Knudsen, Associate Professor from the University of Copenhagen | Videnskab DK)

Model: 16-month-old female C57BL/6 mice 
Dosage: 60 mg/kg/day of ABT-263 dissolved in drinking water for 7 days on, 7 days off, and 7 days on again

A senolytic compound and anti-cancer drug called ABT-263 accelerates ovarian aging in aged mice, suggesting it promotes infertility. 

Search Result: senescent cells

Israeli Scientists Proclaim ‘A Healthy Mind Is a Healthy Immune System,’ Revealing How to Slow Brain Aging

Can Senolytic Supplements Restore Hair Growth? What the New Research Says

Scientists Identify a Molecule that Mimics the Anti-Aging Effects of Exercise on the Brain

Fresh Insights: NR’s Effects on Inflammation in Age-Related Lung Disease

Which Anti-Aging Senolytic Supplement Should You Avoid?