Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

Esteemed Cardiologist Says Commercial Interests Are Distorting Evidence Behind Statins

Dr. Aseem Malhotra, a cardiologist from the UK, says pharmaceutical company-sponsored research distorts the scientific evidence behind the effectiveness of cholesterol-lowering statins against heart disease.

(Dr. Aseem Malhotra, cardiologist | The Telegraph)

Cardiovascular

Participants: Physically active and healthy older adults 
Dosage: 1 gram of omega-3s (330 mg EPA plus 660 mg DHA) per day, 2,000 IU of vitamin D per day, and 30 minutes of strength training exercises three times per week

While omega-3 supplementation slows biological aging, adding vitamin D and exercise further slows biological aging.

The “father of aging clocks” and senior study author Steve Horvath, PhD, of Harvard University (Image: quantamagazine.org). 

Aging &amp; Longevity

Participants: Healthy older adults 
Dosage: 4 × 5 g/day of creatine monohydrate for 5 days, followed by 1 × 5 g/day for 23 days

Creatine improves vascular health while lowering blood glucose and triglyceride levels in older adults.

Model: 9-month-old male rats 
Dosage: 20 mg/kg of ergothioneine for three weeks

Ergothioneine — a naturally occurring compound found in mushrooms — increases the muscle size of middle-aged rats while extending the lifespan of worms. 


First author of the study, Dunja Petrovic (Image: isas.de)

Search Result: muscle aging

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

Self-Proclaimed Activist and Cardiologist Says Commercial Interests Are Distorting Evidence Behind Statins

Harvard Study Reveals that Omega-3s, Vitamin D, and Exercise Additively Slow Biological Aging

New Pilot Study Reveals How Creatine Affects Heart Health

Ergothioneine Boosts NAD+, Mitigates Muscle Aging, and Prolongs Life, New Study Shows