The most comprehensive brain model reveals that combining NAD+ (nicotinamide adenine dinucleotide) supplementation with diet and exercise powerfully modulates brain aging. 


Model: APP-KI mouse model for Alzheimer’s disease
Intervention: Restricting feeding times within a 6-hour window each day for 3 months.

Intermittent Fasting Blocks Alzheimer’s Disease 

By restricting the feeding of Alzheimer’s model mice to 6 hours a day (18 hours of fasting), scientists prevent memory loss and counter brain pathology. 


Principal Investigator Dr. Paula Desplats | Desplats Lab 

Discover the groundbreaking research from UC San Diego demonstrating how intermittent fasting improves memory and alleviates brain pathology in Alzheimer's disease. Explore the implications of this study at NAD.

Intermittent Fasting Enhances Memory and Rescues Brain Pathology in Alzheimer's: UC San Diego Study | NAD

Brain &amp; Neurons

Model: SIRT6-defecient 129Sv mice
Dosage: High-fat diet consisting of 16% carbohydrates, 19% protein, and 65% fat (from mostly coconut oil)

A high-fat diet significantly increases the lifespan of prematurely aged mice, restoring their blood glucose levels, reducing the spread of harmful bacteria, and reducing markers of aging. 


Compared to normal mice (left), mice fed gut bacteria from short-lived mice display features of aging, such as gray hair (right). 

Aging &amp; Longevity

Model: female E4FAD mice 
Diet: Day 1 = 55% fat, 36% carbohydrate, and 9% protein. Day 2-5 = 43.3% fat, 47.4% carbohydrate, and 9.3% protein.

Fasting-Mimicking Diet Reduces Alzheimer’s Pathology

Feeding Alzheimer’s model mice a diet low in protein but high in fats reduces brain inflammation, restores new neuron production, and improves cognition. 


Senior author, Dr. Volter D. Longo | USC Pressroom 

Model: 5XFAD mice, transgenic for five familial AD (FAD) mutations
Dosage: 76% fat, 16% protein, 3% carbohydrate, and 5% dietary fiber (by calories)

Ketogenic Diet Restores Alzheimer’s Memory Deficits and Neurodegeneration

Chinese scientists find that a high-fat, low-carbohydrate diet called the ketogenic diet restores memory deficits and neurodegeneration markers in mice modeling Alzheimer’s disease. 


Search Result: ketogenic diet

Most Comprehensive Study Places NAD+ at Forefront of Countering Brain Aging

Intermittent Fasting Improves Memory and Rescues Brain Pathology in Alzheimer’s: UC San Diego Study

New Study Suggests Plant Fat Could Counter Aging by Reducing Harmful Bacteria from Gut

USC Scientists Reveal that Fasting-Mimicking Diet Reduces Brain Pathology and Cognitive Decline in Alzheimer’s

Ketogenic Diet Restores Alzheimer’s Memory Deficits and Neurodegeneration, Study Shows