Participants: Werner syndrome patients 
Dosage: 1 gram of NR per day for 26 weeks

The NAD+ (nicotinamide adenine dinucleotide) booster NR (nicotinamide riboside) improves cardiovascular health in Werner syndrome patients. 

A child with Werner syndrome (image: britannica.com)

Model: C57BL/6J mice
Dosage: 1 mg/mL for a total of 3 mL daily of abacavir dissolved in drinking water for six months

Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging

Latent viral sequences in DNA have evolved with mutations to render them inactive, yet the most recently inherited of these lack suppression, and their activity drives aging.

(Transmission electron microscopy images of young human cells treated with medium from young cells [top] and senescent cells [bottom]. The cell on the bottom treated with senescent cell medium exhibits a dark circle that is a retrovirus-like protein.)

Viral sequences inserted into DNA during ancient viral infections can become activated as we get older, driving cellular senescence and aging.

Model: Sprague-Dawley rats
Dosage: 500 mg/kg/day nicotinamide riboside or 100 mg/kg/day metformin hydrochloride in drinking water

Metformin and nicotinamide riboside (NR) both alleviate inflammation and fibrosis (tissue scarring from damage) in multiple organs from elderly rats.

Model: Sprague Dawley rats
Dosage (oral): 0.1 mg/kg chloroquine

Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Chinese researchers show that the anti-malaria drug chloroquine moderately extends the lifespan and rejuvenates the organs of elderly rats.

Kat7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

CRISPR-induced KAT7 gene inactivation rejuvenates prematurely aging human cells and mice and promotes longevity.

Search Result: Werner syndrome

NAD+ Precursor NR Improves Heart Health in People with Accelerated Aging, New Study Shows

Latest Report: Ancient Virus Reawakens in Older Ages to Accelerate Aging

Scientists Find Metformin and NR Comparably Limit Deterioration of Multiple Organs

Study Shows Chloroquine Extends Lifespan and Rejuvenates Multiple Organs

Researchers Develop an Anti-Aging CRISPR-Based Gene Therapy