Model: Cybrids composed of Rho0 cells with human platelet mitochondrial DNA from participants between 7 days old and 99 years old 
Dosage: 5 mM of n-Acetyl-L-Cysteine and 3 mM of nicotinamide riboside, with medium changed every three days until the cell population reached between 1 and 10 million

New Study: Combining NR with NAC May Slow Telomere Shortening

New research suggests that nicotinamide riboside (NR) combined with N-acetyl cysteine (NAC) prevents telomere shortening linked to genetic sequences within the cell’s powerhouse (mitochondria) in human cells.

(Telomeres [highlighted in gold] at the ends of a chromosome | NAD.com)

A new study suggests the NAD+ precursor NR combined with the antioxidant NAC may counteract telomere shortening, a hallmark of aging.

Aging &amp; Longevity

Participants: Healthy middle-aged adults (average age: 55)
Dosage: 100 mg/day of Monarda didyma L. extract, preferably at lunchtime with plenty of water, for 12 weeks

An extract made from Monarda didyma L. reduces the biological age of older adults while improving their quality of life. 

A flower from the Monarda didyma L. plant (image: nativeplanttrust.org) 

Clinical Trials

Human studies show that a higher intake of the naturally occurring molecule spermidine may prevent cognitive impairments and dementia while improving longevity. 


Brain &amp; Neurons

The UN’s Brief on the Biology of Aging

A new brief from the United Nations (UN) Scientific Advisory Board examines the latest developments in geroscience—a field devoted to delaying, preventing, and treating diseases linked to aging.

A new United Nations brief examines how researchers are addressing an aging global population with geroscience—a field seeking to understand how to intervene against aging.

Discover proven anti-aging and longevity drugs that extend lifespan. Lifestyle, nutrition, sleep, exercise, and toxin avoidance, all in the best and most comprehensive guide.

Explore the most effective longevity interventions—nutrition, fasting, sleep, exercise, and mouse-tested drugs that extend lifespan in real studies.

Search Result: Oxidative Stress

New Study: Combining NR with NAC May Slow Telomere Shortening

Flower Extract Slows Cellular Aging, New Study Shows

Spermidine: A Promising Nutrient for Brain Health and Cognitive Aging

The UN’s Brief on the Biology of Aging

Longevity Prescription