Model: C57BL/6N male mice 
Dosage: AIN-93 M diet with 0.025% (15 mg/kg per day) niclosamide for the Old + NL group or 0.050% (30 mg/kg per day) niclosamide for the Old + NH group, starting at 12 months of age to 21 months of age

Drug Approved Against Tapeworms May Counteract Aging, Suggests New Study

New research suggests niclosamide, approved for human use against tapeworms, alleviates frailty and suppresses the protein complex mTOR, which regulates cell growth, in aged mice.

(The drug niclosamide | Hospital Pharmacy Europe)

Niclosamide, an agent approved for human use against tapeworms, alleviates age-related frailty, suppresses mTOR, and activates autophagy in old mice.

Aging &amp; Longevity

Participants: healthy adults between the ages of 50 and 81
Dosage: 5 mg/week or 10 mg/week of rapamycin

One of the most potent anti-aging compounds rapamycin — an FDA-approved drug that inhibits mTOR — increases the lean body mass of older women while reducing their pain. 


Senior investigator Sajad Zalzala, MD (image: cnbc.com)

Clinical Trials

Participants: Middle-aged adults carrying two copies of the APOE4 gene 
Dosage: 1 mg/kg/day of rapamycin for 4 weeks

The prescription drug rapamycin a.k.a. sirolimus, an FDA-approved mTOR inhibitor, increases the brain volume of cognitively normal individuals at risk for developing Alzheimer’s disease. 


One of the study’s investigators, Talissa Altes, M.D. (Image: Missouri.edu).

Brain &amp; Neurons

Model: Male Sprague Dawley rats
Dosage: 1.5 mg/kg body or rapamycin injected 3 times a week for 4 weeks

The longevity-associated drug rapamycin diminishes muscle size and strength in young rats when compared to untreated but calorically restricted young rats. 

Skin &amp; Muscle

Transplanting a population of “young” stem cells from old mice prolongs the lifespan of middle-aged mice and delays manifestations of aging. 

Search Result: Organ Transplant

Drug Approved for Humans Against Tapeworms May Counteract Aging, Similar to Rapamycin, Suggests New Study

Anti-Aging Supplement Rapamycin Increases Muscle and Reduces Pain: New Results

Neurodegeneration Reversed with mTOR Inhibitor Drug in New Alzheimer’s Study

If Too Young, Rapamycin Isn’t the Anti-Aging Remedy for You, Says New Research

New Study Shows Stem Cells Stop Aging and Prolong Life