Participants: Older adults (ages 60 to 80) with mild cognitive impairment 
Dosage: 320 mg/day of anthocyanin capsules for 24 weeks

Anthocyanin, a compound found in berries, reduces inflammation and heart disease markers in older adults at risk for dementia.  

Lead author of the study, Dr. Miguel Germán Borda (image: noticias.cun.es).

Cardiovascular

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

A naturally occurring compound, α-lipoic acid, helped elderly mice think like younger mice by restoring energy balance and calming brain inflammation, according to Second Hospital of Hebei Medical University researchers.

(Alpha-lipoic acid’s molecular structure | Sasha’s of Saratoga)

Brain &amp; Neurons

Participants: Healthy overweight adults between the ages of 45 and 55 
Dosage: 3 grams/day of ginseng for 28 days

Ginseng Boosts NAD+ and Telomeres: New Study in Middle-Aged Adults

Ginseng supplementation boosts NAD+ (nicotinamide adenine dinucleotide) and lengthens telomeres in middle-aged adults, suggesting an amelioration of aging. 


Panax ginseng Meyer (image: farmaimpresa.com).

Aging &amp; Longevity

Model: 11-month-old male C57BL/6J mice 
Dosage: 30 mg/kg/day of NTX-748 (based on a small molecule called 78c) for 4 months, administered orally

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance

Buck Institute scientists find that blocking the CD38 enzyme, which elevates NAD+ (nicotinamide adenine dinucleotide), counteracts age-related cognitive and physical decline in mice.  

Study conducted at the Buck Institute for Research on Aging (image: linkedin.com).

Model: 22-month-old male C57BL/6NIH mice 
Dosage: 400 mg/kg of NR for eight weeks, administered in food

Treating aged mice with the NAD+ (nicotinamide adenine dinucleotide) precursor NR (nicotinamide riboside) improves memory and reduces pro-inflammatory immune cells.

Senior members of the research team, Dr. Bruce R. Troen and Dr. Kenneth L. Seldeen (image: buffalo.edu).  

Search Result: Mild Cognitive Impairment

Anthocyanin Supplement Shows Anti-Inflammatory and Heart Health Benefits in New Study

Mitochondria-Made Molecule Reverses Memory Loss with Advanced Age

Ginseng Boosts NAD+ and Telomeres: New Study in Middle-Aged Adults

Blocking NAD+ Breakdown Improves Cognitive and Physical Performance: New Study

NAD+ Supplement Improves Memory & Brain Immune Cells, New Study Reveals