Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Aging &amp; Longevity

Cell Reprogramming: True Age Reversal Technology

A gene manipulation technique called cellular programming extends the lifespan of mice and reverses signs of aging in multiple studies, leading to large financial investments in this new technology.  


A stem cell visualized under the microscope with fluorescence. (shutterstock.com | DrimaFilm)

German scientists find that genetic reprogramming — a rising technology that reverts cells to an earlier stage of development — improves heart regeneration after heart attack in mice. 


Max Planck Institute for Heart and Lung Research

Dose: 14 mg/kg rapamycin
Adminisration: mixed in chow (food)

Rapamycin Extends Lifespan by Reorganizing DNA 

German and British scientists find that rapamycin, an inhibitor of mTOR, increases histone protein levels, leading to increased autophagy, improved gut health, and slightly increased lifespan in flies. 


Search Result: Max Planck Institute

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

The Emergence of Cellular Reprogramming: True Age Reversal Technology

Age-Reversing Technology Promotes Heart Repair After Heart Attack: German Study

Rapamycin Improves Longevity and Gut Health Through Rearrangement of DNA