Model: UM-HET3 Mice 
Dosage: 0, 75, 150, 300, 600, and 1200 ng epicatechin/mg food; 0, 0.075, 0.15, 0.3, 0.6, and 1.2 ng halofuginone/mg food; and 0, 37.5, 75, 150, 300, and 600 ng mitoglitazone/mg food, all given ad libitum in food starting at seven months old

Three Compounds Show Promise for Male Longevity

Data from a rigorous longevity study show promise for three new compounds, adding to the repertoire of mouse lifespan-extending substances.

(The three compounds’ effects on median lifespan extension | Rapamycin Longevity News)

The world’s most rigorous longevity study presents data showing promise for three new lifespan-extending compounds in male mice.

Aging &amp; Longevity

Model: C3B6F1 hybrid mice 
Dosage: 42 mg/kg of rapamycin and 1.44 mg/kg of trametinib in food starting at 6 months of age

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Researchers at the Max Planck Institute have unveiled that combining trametinib with rapamycin, drugs used in cancer treatment, extends average lifespan by 29% in female mice and 27% in male mice, respectively.

(The study’s lead author, Linda Partridge | The Biologist)

Combining two cancer treatment drugs, trametinib and rapamycin, extends lifespan by 29% and 27% in middle-aged female and male mice, respectively.

Model: UM-HET3 mice
Dosage: Astaxanthin was fed at 4,000 ppm in the diet beginning after weaning
Meclizine was fed at 800 ppm in the diet beginning after weaning
Administering fisetin started at 20 months old and was fed continuously or a repeated cycle of three days on and 11 days off at a target of 600 ppm in the diet

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

A consortium that examines longevity interventions in mice has found that the anti-nausea compound meclizine as well as the antioxidant astaxanthin extend male mouse lifespan.

(A long-lived mouse surrounded by potential lifespan-extending compounds | NAD.com)

A consortium of researchers has identified the anti-seasickness drug meclizine and the antioxidant astaxanthin as two compounds that significantly extend male mouse lifespan.

Limited rapamycin exposure late in life was as effective as continuous exposure in increasing survival in males but not females

Late-life rapamycin administration regimens enhance mouse lifespan in a sex-dependent manner with limited exposure more effective in males than females.

Search Result: Jackson Laboratory

Three Compounds Show Promise for Male Longevity

Latest Research: Two FDA-Approved Drugs Additively Extend Lifespan

Over-the-Counter Wonders: New Research Highlights Two Compounds for a Longer Life

Late-Life Rapamycin Dosing Regimens Extend Mouse Lifespan in a Sex-Specific Manner