Model: Male Monkeys 
Dosage: 20 mg/kg of metformin

Supplementation of metformin — a first-line treatment for type 2 diabetes and the second-most prescribed medication in the U.S. — improves the learning and memory of older monkeys. 

Brain &amp; Neurons

Model: Adults with an average age of 61
Dosage: 1.2 grams of CoQ10 or 1.0 grams of NR administered orally daily for six weeks

What the New Kidney Disease Study Says About NR and CoQ10

Researchers conducted a human trial suggesting that nicotinamide riboside (NR) or CoQ10 supplementation improves metabolism and immunity.

(Three patients with chronic kidney disease undergoing a human trial | NAD.com)

NR or CoQ10 supplementation enhances gene activity associated with metabolism and immunity, CoQ10 reduces protein markers of inflammation, and NR improves mitochondrial function in patients with chronic kidney disease.

Scientists find that limiting folate (vitamin B9) beginning at mid-age leads to slowed aging in mice. 

Is reducing vitamin B9 intake good or bad in older age?

Aging &amp; Longevity

Scientists find microplastics — small pieces of plastic — in human brain, kidney, and liver samples.

High levels of plastic found in human brain tissue. 

Model: Humans between the ages of 21 and 72
Dosage: Oral dosage of 500 mg of nicotinamide, 600 mg of alpha lipoic acid, 10 mg of zinc, 20 mg of vitamin C, and 2,110 mg of a botanical blend containing green tea extract, rutin, parsley leaf extract, and black pepper fruit daily for 28 days

A New, Multifaceted Approach to Maximizing Cellular NAD+ Levels

British researchers designed a nutraceutical to maximize nicotinamide adenine dinucleotide (NAD+) levels that significantly lowers biological age.

British researchers used a nutraceutical targeting multiple NAD+ biosynthesis- and breakdown-related enzymes to increase NAD+, lower inflammation, and increase sirtuins.

Search Result: Inflammation

Metformin Slows Brain Aging in Older Monkeys, New Research Shows

What the New Kidney Disease Study Says About NR and CoQ10

How Not Eating Leafy Greens Can Make You Age Slower

Microplastics May Cause Alzheimer’s Disease

A New, Multifaceted Approach to Maximizing Cellular NAD+ Levels