Model: Primary hippocampal neurons from non-transgenic C57BL/6 (nTg) and triple-transgenic 3xTg-AD mice; age groups: young (2–6 mo), middle (8–11 mo), and old (17–28 mo).
Dosage: Nicotinamide 2 mM + EGCG 2 µM applied to cultured neurons for 16 h (in vitro).

Study shows that brief nicotinamide + EGCG treatment restores neuronal energy in 16–24 hours, restores autophagy, reduces amyloid-beta buildup, and boosts neuron survival by ~22% in aging/Alzheimer’s lab models.

Brain &amp; Neurons

Model: 9-month-old male rats 
Dosage: 20 mg/kg of ergothioneine for three weeks

Ergothioneine — a naturally occurring compound found in mushrooms — increases the muscle size of middle-aged rats while extending the lifespan of worms. 


First author of the study, Dunja Petrovic (Image: isas.de)

Skin &amp; Muscle

Supplementing with ergothioneine — a compound found in lion’s mane mushrooms — enhances the verbal memory of elderly individuals. 

(Image: marthastewart.com) Lion’s mane mushrooms.

Bruce N. Ames, PhD, reveals his 11 longevity vitamins — molecules that activate long-term health enzymes — as part of his Triage Theory of aging. 

Triage Theory is named after the assortment system the French Army used during World War I called Triage, which prioritized the treatment of injured soldiers. 

Aging &amp; Longevity

Model: Twenty-five-month-old female Sprague-Dawley rats
Dosage: 1 mL of blood plasma from two-month-old rats intraperitoneally injected every other week until death
Model: C57BL/6J male mice
Dosage: 0.055 mg/mL of ergothioneine administered orally in water from seven weeks of age until death

Canadian Longevity Organization Spotlights Key Research on Latest Anti-Aging Treatments

The Canadian Longevity Association — a non-profit organization dedicated to accelerating longevity research — highlights research on rodent lifespan extension with young plasma and the mushroom-derived compound ergothioneine.

(Canadian Longevity Association | Facebook)

The Canadian Longevity Association presents new findings showing that injecting young plasma into older individuals and mushroom-derived ergothioneine extend lifespan in rodents.

Search Result: Ergothioneine

Nicotinamide + Ergothioneine Reboot Autophagy and Ease Hallmarks of Brain Aging

Ergothioneine Boosts NAD+, Mitigates Muscle Aging, and Prolongs Life, New Study Shows

Ergothioneine Longevity Supplement Enhances Verbal Memory

Bruce Ames’ Triage Theory & The Eleven Longevity Vitamins

Canadian Longevity Organization Spotlights Key Research on Young Plasma and Mushroom-Based Anti-Aging Treatments