The Most Important Anti-Aging Drugs and Interventions

President and CEO of the Buck Institute for Research on Aging Eric Verdin, M.D., discusses the future of anti-aging drugs and the most important interventions to improve lifespan. 

Aging &amp; Longevity

Physicist Turned Aging Researcher Dr. Andrew Steele's Top Five Most Exciting Anti-Aging Drugs

Steele discusses the evidence backing five potential lifespan-extending drugs but says we need to wait and watch to see if they are safe and effective for humans.

(The most exciting REAL anti-aging drugs | Andrew Steele on YouTube)

Dr. Andrew Steele reviews the top five anti-aging drugs that he finds the most promising: rapamycin, senolytics, metformin, taurine, and statins.

Model: HSCs derived from the bone marrow of anonymous old adults (58–77 years old); Old mice (81–84 weeks old).
Dosage: Old mice were fed with a control (black) or urolithin A (UA) supplemented (red) diet (50 mg kg/day) for 16 weeks.

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds 

This mitochondrial modulator helps old human blood stem cells grow and copy themselves more efficiently, and it also helps blood stem cells make blood and immune systems for old mice. 


Immunity

Model: C57/B6 female mice
Dosage: 300 mg/kg of ꞵ-hydroxybutyrate intraperitoneally injected three times per week for four weeks

Intermittent Fasting Potently Suppresses Tumor Growth: New Study Findings

Researchers show that intermittent fasting — going without food for 16-hour intervals per day — reduces tumor growth and extends lifespan in mice with ovarian cancer.

(A mouse with an ovarian tumor next to a dish of food in a laboratory | NAD.com)

Intermittent fasting significantly extends remaining lifespan and suppresses tumor growth in mice with an aggressive and lethal form of ovarian cancer.

Cancer

Model: NOD/SCID mice
Dosage: 3.4 mg/kg/day of neopetroside-B injected for three consecutive days

NAD+ Boosting Neopetroside-B Protects the Heart and Suppresses Cancer

Researchers show treatment with the nicotinamide adenine dinucleotide (NAD+) precursor neopetroside-B increases heart cell survival, prevents chemotherapy-induced heart scarring, and reduces tumor volume in mice.

(The molecular structure of the NAD+ precursor neopetroside-B)

Discover groundbreaking findings from a Korean study on Neopetroside-B's remarkable role in safeguarding the heart during chemotherapy while also exhibiting cancer-suppressing properties. Learn how NAD augmentation holds promise for enhanced cancer treatments.

Search Result: Chemotherapy

Longevity Expert Dr. Eric Verdin: The Most Important Anti-Aging Drugs and Interventions

Physicist Turned Aging Researcher Dr. Andrew Steele: The Five Most Exciting Anti-Aging Compounds

Urolithin A Can Revitalize Blood Stem Cells in People and Mice, Study Finds

Intermittent Fasting Potently Suppresses Tumor Growth to Prolong Survival: New Study Findings

NAD⁺ Boosting Molecule Protects the Heart Against Chemotherapy and Suppresses Cancer: Korean Study