Model: Otherwise healthy adults aged 40 and older
Dosage: 15 g of the multi-ingredient supplement dissolved in up to 500 mL of water or juice, given each day orally for six months

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

A six-month human trial found that a multi-ingredient nutritional supplement improved vascular health, reducing arterial stiffness and lowering systolic blood pressure.

(An image depicting increased arterial stiffness [measured with pulse-wave velocity] and blood pressure, along with reduced flow-mediated dilation in aged blood vessels | NAD.com)

A six-month randomized trial found that a multi-ingredient supplement improved vascular health markers, including arterial stiffness and blood pressure.

Cardiovascular

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

Aging guru Bryan Johnson shares his latest daily longevity protocol, which he uses to optimize measurements of his body’s aging.

(A futuristic image of Bryan Johnson | YouTube)

Venture capitalist and aging guru Bryan Johnson reveals his latest longevity-focused daily routine for 2025, focusing on sleep, exercise, and eating well.

Aging &amp; Longevity

Participants: Healthy older adults 
Dosage: 4 × 5 g/day of creatine monohydrate for 5 days, followed by 1 × 5 g/day for 23 days

Creatine improves vascular health while lowering blood glucose and triglyceride levels in older adults.

Model: 27-month-old male C57BL/6N mice 
Intermittent Dosing (oral): 1 week of 100 mg/kg/day of fisetin, followed by 2 weeks of no intervention, followed by 1 week of 100 mg/kg/day of fisetin

Fisetin supplementation counteracts artery aging in old mice by preserving artery elasticity and function via senolytic action — removal of senescent (dysfunctional) cells.  


Lead investigator Sophia Mahoney | University of Colorado Boulder

The latest scientific research indicates that both resistance and aerobic exercise are necessary for maximizing longevity and promoting overall health. 

Search Result: Arterial stiffness

Can a Nutritional Supplement Prevent Vascular Aging? 6-Month Human Trial Results

Longevity Fanatic Bryan Johnson’s Daily Aging Intervention Routine for 2025

New Pilot Study Reveals That Creatine Improves Heart Health

Senolytic Compound Fisetin Preserves Artery Wall Elasticity to Combat Cardiovascular Disease

Engaging in Regular Physical Activity: A Key Strategy for Enhancing Longevity and Overall Health