Top Evidence-Based Interventions to Lower Biological Age

Epigenetic aging clocks estimate biological age based on DNA molecular tagging patterns, and interventions like semaglutide and ketamine reduce these estimates in humans.

(The principal investigator behind the review on interventions that influence biological age, Dr. David Sinclair | The Society of the Four Arts)

As reviewed in this article, epigenetic aging clocks have estimated the effects of pharmaceutical interventions, lifestyle habits, supplements, and clinical interventions on biological age.

Aging &amp; Longevity

Duke University scientists have successfully induced new neuronal connections in the brains of mice, leading to improvements in social interaction and stress resilience. 

Brain &amp; Neurons

Participants: Sedentary older adults 
Dosage: 6 mg/week of rapamycin

In older adults, the FDA-approved drug rapamycin, associated with prolonging lifespan, blunts improvements in physical performance.

Skin &amp; Muscle

Model: C57BL/6 mice
Dosage: 500 mg/kg/day of SRN-901 via oral gavage for six days per week starting at 18 months of age; 14.4 ppm of rapamycin mixed in food starting at 18 months of age; 300 mg/kg/day of NMN via oral gavage for six days per week starting at 18 months of age; and 300 mg/kg/day of NR via oral gavage for six days per week starting at 18 months of age

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

In a newly published mouse study, SRN-901 extended remaining lifespan by 33%, slowed frailty progression, and lowered tumor incidence.

Seragon’s SRN-901 extended the remaining lifespan of adult mice by 33%, attenuated frailty progression by 70%, and reduced tumor incidence by 30.53%, according to a newly published preclinical study.

Participants: Healthy adults 
Dosage: An escalating dose of niacin (250-1000 mg/day) for 16 weeks

Finnish scientists used a new measurement system to detect low NAD+ levels in blood samples from people with a range of age-related conditions, but not in healthy older individuals.


Principal Investigator of the study, Dr. Anu Suomalainen (image: helenski.fi).

Search Result: Alzheimer

Top Evidence-Based Interventions to Lower Biological Age

Can We Reverse Memory Loss? Duke Scientists Find New Way to Rewire the Brain

Rapamycin and Exercise: New Study Finds Potential Performance Decline

Seragon Publishes Record-Breaking SRN-901 Longevity Data, Demonstrating 33% Lifespan Extension in Mice

NAD+ Levels in Healthy Aging: New Study Reveals Surprising Trends