Aging & Longevity

Physician-Entrepreneur Peter Diamandis’s Top Supplement Picks for 2024

Dr. Peter Diamandis, the founder of XPrize — which awards millions to those who can develop cutting-edge technologies like aging vaccines — takes a comprehensive approach to longevity-focused supplementation.

By Bennett M. Sherman

Key Points:

  • Dr. Diamandis takes the nicotinamide adenine dinucleotide (NAD+) precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) at undisclosed doses.
  • Other daily supplements for general health and cognition include creatine, alpha-lipoic acid, and lion’s mane mushrooms.
  • Dr. Diamandis has also explored extracting and storing his own stem cells for future stem cell therapy and plasma exchange — where blood plasma is replaced with saline for regenerative potential.

Dr. Peter Diamandis, an American physician and entrepreneur who founded the XPrize — which awards millions of dollars to those who create new longevity technologies — has revealed his lifespan-focused supplement protocol via his website. Some of the supplements he takes include the following:

Dr. Diamandis uses the following quote from futurist Ray Kurzweil on his website before relaying his list of supplements along with their possible benefits:

“It’s likely that we’re just another ten to twelve years away from the point that the general public will hit longevity escape velocity.”

Longevity escape velocity is the time at which science will extend life expectancy by one year for every year that elapses. As Dr. Diamandis puts it, he wants to keep himself in optimal health so that he can utilize the lifespan extension technologies on the horizon. With that in mind, he supplements with these compounds to maintain his life without disease (healthspan).

Longevity escape velocity (LEV) will occur when medical breakthroughs extend remaining life expectancy at a pace beyond the risk of death from age-related diseases.
(Longevity escape velocity (LEV) will occur when medical breakthroughs extend remaining life expectancy at a pace beyond the risk of death from age-related diseases. | Growing Life) If LEV is reached at birth (top line), remaining life expectancy will easily outpace the risk of death from age-related diseases. If LEV occurs in midlife (LEV by midlife) or later in life (LEV ‘in the nick of time’), remaining life expectancy will drop with age but increase throughout the later years.

Dr. Diamandis’s Prescription Medications

What’s more, Dr. Diamandis discloses the prescription medicines he takes and gives a brief rationale for each one. He emphasizes that his prescription medicine regimen certainly is not a one-size-fits-all approach but has been tailored to his individual needs. As such, he takes the following prescription medicines in doses that fit his physiological requirements, namely, tamping down high blood levels of cholesterol:

  • Zetia for its unique mechanism to inhibit cholesterol absorption
  • Crestor, a low-dose statin that lowers cholesterol and also has anti-inflammatory, anti-viral, and antioxidant properties
  • Repatha that lowers harmful (LDL) cholesterol

Dr. Diamandis adds that this repertoire of medications has effectively lowered his blood ApoB levels — a protein that serves as a marker for vascular plaques and cardiovascular disease. He adds that his tailored medication profile that works against high cholesterol, elevated ApoB levels, and cardiovascular problems illustrates the power of personalized medicine.

Another prescribed medication that Dr. Diamandis uses to boost his cognition is modafinil. Modafinil is a nootropic — a drug used to enhance memory or other cognitive functions — designed to stimulate wakefulness and mental acuity. Dr. Diamandis says this drug is effective; however, one should not use it unless under professional supervision. Furthermore, you should be aware of its side effects, such as nervousness and anxiety as well as headaches and nausea.

Peptides May Optimize Hormonal Balance

Dr. Damandis also relays that he uses peptides — molecules composed of bonded protein building blocks (amino acids). Peptides that he takes include BPC-157, CJC-1295/Ipamorelin, and others that he does not disclose, all for testosterone optimization. He states that his peptide regimen reflects the nuanced balance that hormone optimization requires for pro-longevity benefits.

Storing Stem Cells for Future Therapeutic Use and Refreshing Blood Plasma

Some more potential longevity-promoting techniques that Dr. Diamandis uses include storing his adult stem cells in biobanks for future use as stem cell therapy. In this way, he says that he is “preparing for the next wave of regenerative medicine.”

What’s more, he is exploring and has used therapeutic plasma exchange (TPE). TPE entails giving blood, having the blood plasma replaced with saline (a mix of salt and water), and then injecting this refreshed blood back into an individual. This process is believed to get rid of some of the inflammatory proteins that come from age-associated dysfunctional cells — senescent cells. Getting rid of these proteins may quell systemic inflammation, and TPE has been associated with slowed cognitive decline in patients with Alzheimer’s disease.

Dr. Diamandis Wants to Be Around for Longevity Breakthroughs in the Coming Decade

Dr. Diamandis says that he is trying to maximize his healthspan so that he will be alive to intercept benefits from the latest longevity breakthroughs predicted to arrive around the next decade. His personalized medication repertoire that works against high cholesterol and optimizes his hormonal balance serves as a testament to personalized medicine. Furthermore, he has curated his supplement stack as a comprehensive approach to improving overall wellness. Interestingly, Dr. Diamandis is also exploring new, cutting-edge ways to extend his healthspan, such as stem cell biobanking and TPE.

With the ethos of longevity-focused wellness in mind, he ends the section on his website describing his supplement repertoire with the following quote from Mahatma Gandhi:

“It is health that is the real wealth, and not pieces of gold and silver.”


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